Phase-Amplitude Coupling Between EEG Cortical Oscillations and Respiration: An Exploratory Study
Phase-Amplitude Coupling Between EEG Cortical Oscillations and Respiration: An Exploratory Study
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DOI：
10.1109/ner52421.2023.10123888
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发表时间：
2023-04
期刊：
影响因子：
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通讯作者：
J. McLinden;S. B. Borgheai;C. Kumar;N. Rahimi;M. Shao;K. Spencer;Y. Shahriari
中科院分区：
文献类型：
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作者：
J. McLinden;S. B. Borgheai;C. Kumar;N. Rahimi;M. Shao;K. Spencer;Y. Shahriari
皮质振荡模式与广泛的功能相关，包括注意力、运动功能和记忆。不同皮层振荡的选择性调制在许多脑机接口（BCI）和神经反馈范例中是令人感兴趣的。最近的研究结果表明，呼吸在调制高频皮层电活动中起着重要作用。然而，这些先前的工作主要依赖于侵入性神经成像方式，并且通过成像技术（包括脑电图（EEG））非侵入性记录的呼吸和皮质振荡之间的关系仍然报道不足。在这项研究中，我们探讨了呼吸信号的相位和幅度之间的相位-幅度耦合（PAC）的EEG频带功率跨越几个频段。我们同时记录了9名健康参与者在听觉任务期间的EEG和呼吸努力，并应用PAC算法来探索呼吸相位和EEG频带功率幅度之间的耦合。我们在所有9名参与者中观察到至少三个通道和一个频段的显著PAC。具体而言，在9名参与者中的5名中至少在3个通道中观察到呼吸-γ PAC，而在9名参与者中的4名中在呼吸-α PAC中观察到类似的模式。这些研究结果加强了以前的观察，在广泛分布的呼吸皮质γ PAC的侵入性研究，同时表明，α波段振荡也可能调制呼吸在一些人。这些结果有助于更好地理解呼吸在高级脑功能中的作用，并可以为未来整合呼吸跟踪的神经反馈范例提供信息。
Cortical oscillatory patterns are associated with a wide range of functions, including attention, motor functions, and memory. Selective modulation of different cortical oscillations is of interest in many brain-computer interface (BCI) and neurofeedback paradigms. Recent findings have suggested that respiration plays a role in modulating higher-frequency electrocortical activity. However, these previous works have mostly relied on invasive neuroimaging modalities, and the relationship between respiration and cortical oscillations recorded non-invasively though imaging techniques, including electroencephalography (EEG), remains underreported. In this study, we explore phase-amplitude coupling (PAC) between the phase of respiration signals and amplitude of EEG band power across several frequency bands. We recorded simultaneous EEG and respiration effort from nine healthy participants during an auditory task and applied a PAC algorithm to explore coupling between respiration phase and EEG band power amplitude. We observed significant PAC in at least three channels and one frequency band across all nine participants. Specifically, respiration-gamma PAC was observed in at least three channels in five of nine participants, while a similar pattern was observed in respiration-alpha PAC in four of nine participants. These findings reinforce previous observations in invasive studies of widely distributed respiration-cortical gamma PAC while suggesting that alpha band oscillations may also be modulated by respiration in some individuals. These results contribute to better understanding of the role of respiration in higher brain functions and could inform future neurofeedback paradigms that integrate respiration tracking.