RISK-FACTORS AND RAISED ATHEROSCLEROTIC LESIONS IN CORONARY AND CEREBRAL-ARTERIES - STATISTICAL-ANALYSIS FROM THE OSLO STUDY
RISK-FACTORS AND RAISED ATHEROSCLEROTIC LESIONS IN CORONARY AND CEREBRAL-ARTERIES - STATISTICAL-ANALYSIS FROM THE OSLO STUDY
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DOI：
10.1161/01.atv.1.4.250
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
STRONG, JP
中科院分区：
文献类型：
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作者：
HOLME, I;ENGER, SC;STRONG, JP
1972-1973年，居住在奥斯陆的大约16,200名年龄在40岁到49岁之间的男性接受了心血管疾病检查，并测量了一些冠状动脉危险因素。本文报告129例尸检病例的结果，探讨冠状动脉和脑动脉动脉粥样硬化病变升高与各种冠状动脉危险因素之间的关系。对于冠状动脉抬高的病变，高密度脂蛋白(高密度脂蛋白)胆固醇比率是最显著的危险因素。收缩压和血清总胆固醇也显著相关。工作和休闲时的体力活动、非空腹甘油三酯和吸烟与冠状动脉病变没有明显的关联。血清总胆固醇与收缩压之间的相关性表明，在影响冠状动脉粥样硬化发展的协同作用中，血清总胆固醇可能比收缩压更重要。对于脑动脉抬高的病变，血压是最重要的危险因素，尽管血清胆固醇与病变高度相关。交互作用分析还表明，在协同作用中，血压比血清胆固醇更重要。
In 1972-1973, about 16,200 men living in Oslo, aged 40 to 49 years, were examined for cardiovascular disease, and had a number of coronary risk factors measured. This report gives the results of 129 autopsied cases with regard to the association between raised atherosclerotic lesions in coronary and cerebral arteries and various coronary risk factors. For coronary raised lesions, the high density lipoprotein (HDL) cholesterol ratio was the most significant risk factor. Systolic blood pressure and total serum cholesterol were also significantly associated. Physical activity at work and at leisure, nonfasting triglycerides, and cigarette smoking did not show a significant association with coronary artery raised lesions. The association between total serum cholesterol and systolic blood indicates that total serum cholesterol may be more important than systolic pressure in the synergism affecting the development of coronary atherosclerosis. For cerebral artery raised lesions, blood pressure was the most important risk factor, even though serum cholesterol was highly associated with the lesions. The interaction analysis also suggested that blood pressure was more important than serum cholesterol in the synergism.