Cone inputs to murine striate cortex
Cone inputs to murine striate cortex
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DOI：
10.1186/1471-2202-9-113
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发表时间：
2008-11-14
期刊：
影响因子：
2.4
通讯作者：
Gouras, Peter
中科院分区：
文献类型：
--
作者：
Ekesten, Bjorn;Gouras, Peter
背景资料：我们已经记录了从单个神经元在小鼠视觉皮层的反应，以确定从两个小鼠视锥光感受器机制的输入的有效性，以及是否有任何独特的选择性锥输入在这个更高的区域的视觉系统，将支持在小鼠的色觉的可能性。每只眼睛被刺激的漫射光，无论是370（强刺激的紫外线（UV）锥视蛋白）或505 nm（专门刺激的中间波长敏感（M）锥视蛋白），获得从发光二极管（LED）在存在一个强大的适应光，抑制杆的响应。两种类型的反应细胞被发现。一种类型（135/323-42%）几乎没有自发活动，并在光刺激的开和/或关相反应，通常具有相对较大幅度的几个脉冲。第二种类型（166/323-51%）有自发活动，对光刺激有紧张性反应，通常是小幅度的脉冲。大多数细胞对两种光谱刺激的反应相似。少数（18/323-6%）反应强烈或专门的一个或其他光谱的刺激，很少在光谱对手martens.Conclusion：大多数细胞在小鼠纹状体皮质接收兴奋性输入从UV和M-锥。一小部分显示出对一种或另一种锥机制的强选择性，偶尔也会出现锥对手的反应。细胞，可以根据彩色对比度检测存在，但极其罕见的小鼠纹状体皮质。
Background: We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of colour vision in mice. Each eye was stimulated by diffuse light, either 370 (strong stimulus for the ultra-violet (UV) cone opsin) or 505 nm (exclusively stimulating the middle wavelength sensitive (M) cone opsin), obtained from light emitting diodes (LEDs) in the presence of a strong adapting light that suppressed the responses of rods.Results: Single cells responded to these diffuse stimuli in all areas of striate cortex. Two types of responsive cells were encountered. One type (135/323-42%) had little to no spontaneous activity and responded at either the on and/or the off phase of the light stimulus with a few impulses often of relatively large amplitude. A second type (166/323-51%) had spontaneous activity and responded tonically to light stimuli with impulses often of small amplitude. Most of the cells responded similarly to both spectral stimuli. A few (18/323-6%) responded strongly or exclusively to one or the other spectral stimulus and rarely in a spectrally opponent manner.Conclusion: Most cells in murine striate cortex receive excitatory inputs from both UV- and M-cones. A small fraction shows either strong selectivity for one or the other cone mechanism and occasionally cone opponent responses. Cells that could underlie chromatic contrast detection are present but extremely rare in murine striate cortex.