Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease
Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease
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DOI：
10.1016/j.parkreldis.2010.11.004
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发表时间：
2011-01-01
影响因子：
4.1
通讯作者：
Sobue, Gen
中科院分区：
文献类型：
--
作者：
Hirayama, Masaaki;Nakamura, Tomohiko;Sobue, Gen
背景：氧化应激与帕金森病（PD）的发病机制存在因果关系。氧气会产生大量的活性氧（ROS）。活性氧（ROS）包括羟基自由基和H（2）O（2）与DNA中的鸟嘌呤残基反应生成8-羟基脱氧鸟苷（8-OHdG）。8-OHdG作为氧化应激在各种疾病中的生物标志物。方法：我们调查了61例PD患者和28名正常人的尿8-OHdG水平，以评估各种临床特征的相关性。我们使用统一帕金森病运动症状评定量表量化疾病严重程度结果：使用简易精神状态检查量表（MMSE）对精神功能进行评估，使用鸟取大学幻觉评定量表（TUHARS）对幻觉进行量化。8-OHdG与各项指标均呈显著相关，但排除所有其他参数的贡献后的偏相关系数表明，只有TUHARS和BURRS第3部分与8-OHdG显著相关。特别是，TUHARS相关性最好与尿8-OHdG levels.Conclusion：尿8-OHdG水平和幻觉，但不与痴呆症之间的显着相关性表明，幻觉可能有独特的，但身份不明的机制，导致过量生产的8-OHdG。(C)2010爱思唯尔有限公司版权所有。
Background: Oxidative stress is causally associated with the pathogenesis of Parkinson's disease (PD). Oxygen generates a large amount of reactive oxygen species (ROS). ROS including hydroxyl radicals and H(2)O(2) react with guanine residues in DNA and produce 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG serves as a biomarker for oxidative stress in various diseases.Method: We investigated urinary 8-OHdG levels in 61 PD patients and 28 normal subjects to evaluate the correlation with various clinical features. We quantified disease severity using the Unified Parkinson's Disease Rating Scale for motor symptoms (UPDRS part 3), the Mini-Mental State Examination (MMSE) for mental function, and the Tottori University Hallucination Rating Scale (TUHARS) for quantifying hallucinations.Results: There were significant correlations between 8-OHdG and all the examined parameters, but the partial correlation coefficients excluding contributions of all the other parameters showed that only TUHARS and UPDRS part 3 are significantly related to 8-OHdG. In particular, TUHARS correlates best with urinary 8-OHdG levels.Conclusion: The significant correlation between urinary 8-OHdG levels and hallucinations but not with dementia suggests that hallucinations are likely to have unique but unidentified mechanisms that lead to excessive production of 8-OHdG. (C) 2010 Elsevier Ltd. All rights reserved.