Novel antifungal beta-amino acids: synthesis and activity against Candida albicans.
Novel antifungal beta-amino acids: synthesis and activity against Candida albicans.
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新型抗真菌β-氨基酸：合成和对抗白色念珠菌的活性。
DOI：
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发表时间：
2003
影响因子：
2.7
通讯作者：
W. Schönfeld
中科院分区：
文献类型：
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作者：
J. Mittendorf;F. Kunisch;M. Matzke;Hans;A. Schmidt;W. Schönfeld
合成了一系列新的β-氨基酸，并测试了它们对白色念珠菌的体外抗真菌活性。观察到SAR陡峭。β-氨基酸21（BAY 10-8888/PLD-118）显示出最有利的活性-耐受性特征，并被选择用于临床研究作为口服治疗酵母菌感染的新型抗真菌剂。
A series of novel beta-amino acids has been synthesized and tested for their in vitro antifungal activity against Candida albicans. A steep SAR was observed. beta-Amino acid 21 (BAY 10-8888/PLD-118) revealed the most favourable activity-tolerability profile and was selected for clinical studies as a novel antifungal for the oral treatment of yeast infections.