Effect of antiretroviral therapy on clinical and immunologic disease progression in HIV positive children: One-year follow-up study
Effect of antiretroviral therapy on clinical and immunologic disease progression in HIV positive children: One-year follow-up study
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DOI：
10.4103/2230-8229.102318
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发表时间：
2012-09-01
影响因子：
2.7
通讯作者：
Patel, Priyanka K.
中科院分区：
文献类型：
--
作者：
Patel, Ankur;Trivedi, Sangeeta S.;Patel, Priyanka K.
目的：研究抗逆转录病毒治疗(ART)对人类免疫缺陷病毒(HIV)感染儿童1年的临床、免疫学和营养状况的影响。材料和方法：研究对象为2007年8月至2009年8月在苏拉特艺术中心注册的54名儿童，年龄1.5-15岁。在研究期间，每隔6个月对孩子们进行一次跟踪调查，直到开始接受ART治疗后的1年。世界卫生组织(WHO)的临床分期和国家指南中的CD4细胞计数以及营养状况被用来衡量疾病的临床和免疫进展，最长达1年。结果：在54名儿童中，96.2%的儿童报告母婴传播，74%的儿童父母双方均为HIV阳性。所有患儿均按WHO临床分期和CD4细胞计数(%)分为4个阶段，分别于6个月和12个月进行随访，并报告ART的益处。在12个月的随访中，研究组15%的儿童死亡。研究组患者术后1年的平均CD4计数和相对百分比均有显著增加(P<；0.01)。结论：本研究报告了ART在治疗1年后对HIV感染儿童的临床和免疫学进展、营养状况等方面的益处。
Objective: To study the effect of antiretroviral therapy (ART) on clinical, immunologic, and nutritional progression of disease in human immunodeficiency virus (HIV)-infected children for 1 year. Materials and Methods: The study included 54 children aged 1.5-15 years who registered at the ART center, Surat, from August 2007 to August 2009. During the study period, the children were followed-up at 6 monthly intervals up to 1 year after starting ART. World Health Organization (WHO) clinical staging and CD4 cell count as per national guidelines, and nutritional status were used to measure clinical and immunologic progression of disease up to 1 year. Results: Out of 54 children, mother-to-child transmission was reported in 96.2% children; for 74% of the children, both parents were HIV positive. All the children were classified according to WHO clinical staging into 4 stages and as per CD4 cell count (%), followed up at 6 and 12 months and the benefits with ART reported. At 12 months follow-up, 15% of the study group children had died. Both mean CD4 count and a relative percentage showed significant increase (P < 0.01) in the study group 1 year after ART. Conclusion: The present study reports benefits of ART in terms of clinical and immunologic progression of disease, nutritional status of HIV-infected children after 1 year of ART.