The mechanism of oxidation-induced low-density lipoprotein aggregation: an analogy to colloidal aggregation and beyond?
The mechanism of oxidation-induced low-density lipoprotein aggregation: an analogy to colloidal aggregation and beyond?
复制标题
氧化诱导的低密度脂蛋白聚集的机制：与胶体聚集的类比及其他？
DOI：
10.1016/s0006-3495(01)75887-0
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发表时间：
2001
影响因子：
3.4
通讯作者：
Lin,B
中科院分区：
文献类型：
--
作者：
Xu,S;Lin,B
动脉粥样硬化是一种由脂蛋白聚集和沉积在动脉壁引起的疾病。在这项研究中，从头低密度脂蛋白聚集过程进行了检查。在聚集过程的两个阶段中确定了9个主要中间体。在聚集阶段，低密度脂蛋白分子聚集并形成成核单位。成核单元链接在一起并形成线性聚集体。线性聚集体分支并相互作用，形成分形。在融合阶段，分形中空间相邻的成核单元融合成弯曲的膜表面，其进而融合成多层或单层囊泡。或者，分形中的一些相邻的成核单元以直线聚集并形成棒。随后，棒变平成粗糙的，然后变成光滑的带状物。有时，管状膜囊泡形成的分形。聚集阶段似乎类似于胶体聚集和淀粉样纤维形成。融合阶段似乎是富脂脂蛋白的特征，并且超出胶体聚集和淀粉样纤维形成。
Atherosclerosis is a disease initiated by lipoprotein aggregation and deposition in artery walls. In this study, the de novo low-density lipoprotein aggregation process was examined. Nine major intermediates were identified in two stages of the aggregation process. In the aggregation stage, low-density lipoprotein molecules aggregate and form nucleation units. The nucleation units chain together and form linear aggregates. The linear aggregates branch and interact with one another, forming fractals. In the fusion stage, spatially adjacent nucleation units in the fractal fuse into curved membrane surfaces, which, in turn, fuse into multilamellar or unilamellar vesicles. Alternatively, some adjacent nucleation units in the fractals assemble in a straight line and form rods. Subsequently, the rods flatten out into rough and then into smooth ribbons. Occasionally, tubular membrane vesicles are formed from the fractals. The aggregation stage seems to be analogous to colloidal aggregation and amyloid fiber formation. The fusion stage seems to be characteristic of the lipid-rich lipoproteins and is beyond colloidal aggregation and amyloid fiber formation.