Normal values for esophageal high-resolution manometry
Normal values for esophageal high-resolution manometry
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DOI：
10.1111/nmo.12167
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发表时间：
2013-09-01
影响因子：
3.5
通讯作者：
Smout, A. J. P. M.
中科院分区：
文献类型：
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作者：
Bogte, A.;Bredenoord, A. J.;Smout, A. J. P. M.
背景：食道高分辨率测压(HRM)是一种新的评价食道动力的方法。目前有几个软件和硬件系统可用。在美国，使用专有的触觉传感导管技术(给定成像)，建立了一组HRM参数的正常值。我们希望确定使用另一种导管(Unisensor)进行的HRM的正常值。方法对52例健康志愿者进行仰卧位HRM检查。每个受试者都吞下了10瓶液态水。评估食道收缩参数并计算正常值(定义为值的第5和第95个百分位数)。关键结果计算了下列参数的正常范围：远端收缩积分(平均1319.44，5-95百分位范围[185.65-3407.60])，收缩前沿速度(平均3.98，5-95百分位范围[2.4-6.5])，团注内压(平均9.68，范围[1.00-19.00])，在食管胃交界处上方5厘米测量的收缩幅度(EGJ；移行区(TZ)长度(平均1.34，范围[0.00-5.63])；上段食道括约肌压力(平均81.63，范围[19.50-165.10])；上括约肌长度(平均2.97，范围[2.17-4.00])；EGJ松弛压(平均16.79，范围[1.00-39.35])、IRPs4(平均13.42，范围[2.59-28.28])和胃压(平均5.06，范围[0.00-9.46])。结论&总体而言，用Unisensor导管获得的食道HRM参数的正常值与先前发表的系列结果相似。与食道括约肌和TZ长度相关的参数在正常上限有显著差异。人力资源管理的使用者应该意识到这些差异，并根据与适当正常值的比较来定义病理学。
Background Esophageal high-resolution manometry (HRM) is a novel method to assess esophageal motility. Several software and hardware systems are currently available. A set of normal values for HRM parameters was established in the US, using proprietary tactile-sensing catheter technology (Given Imaging). We wished to determine normal values for HRM performed with another type of catheter (Unisensor). Methods Fifty-two healthy volunteers underwent supine HRM. Each subject swallowed 10 liquid water boluses. Esophageal contraction parameters were evaluated and normal values were calculated (defined as 5th and 95th percentile of values). Key Results The normal range for the following parameters was calculated; distal contractile integral (mean 1319.44, with a 5-95th percentile range [185.65-3407.60]), contractile front velocity (mean 3.98, 5-95th percentile range [2.40-6.50]), Intrabolus pressure (mean 9.68, range [1.00-19.00]), contraction amplitude measured 5 cm above the esophagogastric junction (EGJ; mean 78.76, range [23.00-146.00]), contraction amplitude 15 cm above the EGJ (mean 43.66, range [3.60-96.00]), transition zone (TZ) length (mean 1.34, range [0.00-5.63]), upper esophageal sphincter (UES) pressure (mean 81.63, range [19.50-165.10]), EGJ length (mean 2.97, range [2.17-4.00]), EGJ resting pressure (mean 29.35, range [8.95-51.40]), EGJ relaxation pressure (mean 16.79, range [1.00-39.35]), IRPs4 (mean 13.42, range [2.59-28.28]), and gastric pressure (mean 5.06, range [0.00-9.46]). Conclusions & Inferences Overall, the normal values of esophageal HRM parameters obtained with the Unisensor catheter resemble those of the previously published series. Marked differences in upper limits of normal were found for parameters related to the esophageal sphincters and TZ length. Users of HRM should be aware of these differences and define pathology based on comparison to appropriate normal values.