LOCOMOTION OF FIBROBLASTS IN CULTURE .4. ELECTRON MICROSCOPY OF LEADING LAMELLA
LOCOMOTION OF FIBROBLASTS IN CULTURE .4. ELECTRON MICROSCOPY OF LEADING LAMELLA
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DOI：
10.1016/0014-4827(71)90420-4
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发表时间：
1971-01-01
影响因子：
3.7
通讯作者：
PEGRUM, SM
中科院分区：
文献类型：
--
作者：
ABERCROM.M;HEAYSMAN, JE;PEGRUM, SM
在Araldite基质上运动的鸡心脏成纤维细胞的纵切面电镜显示，细胞在局部区域接近基质，这些区域约占主导薄片下表面面积的四分之一；而靠近这些区域的细胞质，我们认为是粘连，倾向于形成含有纵向细丝的电子致密斑块。有人认为这些斑块与细胞的纤维系统有关。片足（形成褶）具有相当恒定的厚度，并包含一种没有主要细胞器的微弱纤维状细胞质。
Electron microscopy of vertical longitudinal sections of chick heart fibroblasts moving on an Araldite substratum show that the cell approaches close to the substratum in localised regions which in all occupy about one quarter of the area of the lower surface of the leading lamella; and the cytoplasm adjacent to these regions of close approach, which we suggest are adhesions, tends to form electron-dense plaques containing longitudinal filaments. There are suggestions that the plaques are linked up to the fibrillar system of the cell. The lamellipodia (which form the ruffles) are of rather constant thickness, and contain a faintly fibrillar cytoplasm devoid of major cell organelles.