Methods of synthesis of hydrogels … A review.
Methods of synthesis of hydrogels … A review.
复制标题
DOI：
10.1016/j.jsps.2015.03.022
复制
发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Ranjha NM
中科院分区：
文献类型：
--
作者：
Akhtar MF;Hanif M;Ranjha NM
近年来，水凝胶被用于生物活性分子(特别是药物蛋白)的控制释放，如基质和活细胞的包埋。水凝胶的生物可降解性引起了人们对药物输送系统的极大兴趣。最初的三维结构分解成无毒物质，以确定凝胶的良好生物相容性。化学交联法是形成具有优异机械强度的水凝胶的有效方法。水凝胶制剂中使用的交联剂应在使用前从水凝胶中提取，因为据报道它们具有毒性。物理交联法制备水凝胶是交联剂毒性的替代方案。
Hydrogels are being investigated recently for the bioactive molecules (in particular pharmaceutical proteins) controlled release, such as matrices, and for the living cells encapsulation. Biodegradable nature of hydrogels has created much interest for drug delivery systems. The original three-dimensional structure disintegrates into nontoxic substances to ascertain an excellent biocompatibility of the gel. Chemical cross-linking is the highly resourceful method for the formation of hydrogels having an excellent mechanical strength. Cross-linkers used in hydrogel preparation should be extracted from the hydrogels before use due to their reported toxicity. Physically cross-linked methods for preparation of hydrogel are the alternate solution of cross-linker toxicity.