Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides
Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides
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DOI：
10.1039/b600026f
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发表时间：
2006-04-14
影响因子：
4.9
通讯作者：
Majima, T
中科院分区：
文献类型：
--
作者：
Kimura, T;Kawai, K;Majima, T
将环境敏感荧光团dan（6-二甲氨基-2-酰基萘）修饰的dC或dG碱基引入Z-DNA形成序列中。结果表明，Z-DNA的两个凹槽比B-DNA的凹槽更水合。丹将有助于探测DNA多态性之间的凹槽中的微环境。
The environment-sensitive fluorophore dan (6-dimethylamino-2-acyl-naphthalene)- modified dC or dG bases were introduced into the Z-DNA forming sequence. It was demonstrated that both grooves of Z-DNA are more hydrated than those of B-DNA. Dan will be useful for probing the microenvironments in the grooves among the DNA polymorphs.