Anti-inflammatory compounds from leaves and root bark of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg.
Anti-inflammatory compounds from leaves and root bark of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg.
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DOI：
10.1016/j.jep.2007.08.043
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发表时间：
2008-01-04
影响因子：
5.4
通讯作者：
Quetin-Leclercq, J.
中科院分区：
文献类型：
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作者：
Mavar-Manga, H.;Haddad, M.;Quetin-Leclercq, J.
Alchornea cordifolia 是整个非洲传统医学中使用最广泛的植物之一，主要用于治疗炎症、抗菌和寄生虫疾病。为了继续研究其抗炎活性，我们分馏叶和根皮提取物并分离出六种化合物，这些化合物在使用剂量为 go mu g/cm(2) 的巴豆油的小鼠耳水肿模型中表现出显着的局部抗炎活性。胡萝卜素 (2)、乙酰油桐酸 (4)、N1,N2-二异戊烯基胍 (5) 和 N1,N2,N3-三异戊烯基胍 (6) 比吲哚美辛活性更高，而 P-谷甾醇 (1) 和邻苯二甲酸二(2-乙基己基)酯 (3) 则效果较差。这是首次报道该植物中存在化合物 1、2、3 和 4，以及化合物 3、5 和 6 的抗炎活性。这些化合物可能至少部分解释了心叶心叶在民间医学中用于治疗炎症的用途。 (c) 2007 Elsevier Ireland Ltd. 保留所有权利。
Alchornea cordifolia is one of the most widely-used plants in traditional medicine throughout Africa, principally for inflammatory, antimicrobial and parasitic diseases. In continuation of our investigations on its anti-inflammatory activity, we fractionated the leaf and root bark extracts and isolated six compounds which exhibited significant topical anti-inflammatory activity in the mouse ear oedema model using croton oil at a dose of go mu g/cm(2). Daucosterol (2), acetyl aleuritolic acid (4), N1,N2-diisopentenyl guanidine (5) and N1,N2,N3-triisopentenyl guanidine (6) were shown to be more active than indomethacin, while P-sitosterol (1) and di(2-ethylhexyl) phthalate (3) were less effective. This is the first report on the presence of compounds 1, 2, 3 and 4 in this plant and of the anti-inflammatory activity of 3, 5 and 6. These compounds may account, at least in part, for the use of A. cordifolia in folk medicine to treat inflammation. (c) 2007 Elsevier Ireland Ltd. All rights reserved.