Physiological Pattern of Disease Assessed by Pressure-Wire Pullback Has an Influence on Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance Insights From the Multicenter AJIP Registry
Physiological Pattern of Disease Assessed by Pressure-Wire Pullback Has an Influence on Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance Insights From the Multicenter AJIP Registry
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DOI：
10.1161/circinterventions.118.007494
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发表时间：
2019-05-01
影响因子：
5.6
通讯作者：
Davies, Justin E.
中科院分区：
文献类型：
--
作者：
Warisawa, Takayuki;Cook, Christopher M.;Davies, Justin E.
背景：在大约20%的病例中，分数血流储备（FFR）和瞬时无波比（iFR）在冠状动脉病变的血流动力学意义上不一致。目前尚不清楚疾病的生理模式是否是一个影响因素。本研究评估了冠状动脉疾病的生理模式是否影响FFR和iFR测量之间的不一致。方法和结果：360例中度冠状动脉病变（345例患者，平均年龄64.4±10.3岁，76%为男性）合并FFR、iFR和iFR压丝回拉，从国际多中心注册中心纳入分析。血流动力学意义的切点为FFR
BACKGROUND: Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) disagree on the hemodynamic significance of a coronary lesion in approximate to 20% of cases. It is unknown whether the physiological pattern of disease is an influencing factor for this. This study assessed whether the physiological pattern of coronary artery disease influences discordance between FFR and iFR measurement.METHODS AND RESULTD: Three-hundred and sixty intermediate coronary lesions (345 patients; mean age, 64.4 +/- 10.3 years; 76% men) with combined FFR, iFR, and iFR pressure-wire pullback were included for analysis from an international multicenter registry. Cut points for hemodynamic significance were FFR