Biomaterial microlasers implantable in the cornea, skin, and blood.
Biomaterial microlasers implantable in the cornea, skin, and blood.
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DOI：
10.1364/optica.4.001080
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发表时间：
2017-09-20
期刊：
影响因子：
10.4
通讯作者：
Yun SH
中科院分区：
文献类型：
--
作者：
Humar M;Dobravec A;Zhao X;Yun SH
可植入生物组织的独立激光粒子具有实现新型光学成像、诊断和治疗的潜力。在这里，我们展示了几种类型的生物相容性微激光器及其在生物系统中的激光作用。将染料掺杂的聚苯乙烯珠嵌入角膜中并进行光泵浦以产生窄带发射。我们用聚乳酸-羟基乙酸共聚物和聚乳酸制造了微珠，这些物质被批准用于医疗用途，并展示了从组织和全血中发射激光。此外，我们展示了生物相容性胆固醇衍生物微滴激光器通过自组装到洋葱状的径向共振光子晶体结构。
Stand-alone laser particles that are implantable into biological tissues have potential to enable novel optical imaging, diagnosis and therapy. Here we demonstrate several types of biocompatible microlasers and their lasing action within biological systems. Dye-doped polystyrene beads were embedded in the cornea and optically pumped to generate narrowband emission. We fabricated microbeads with poly(lactic-co-glycolic acid) and poly(lactic acid)—substances approved for medical use—and demonstrate lasing from within tissues and whole blood. Furthermore, we demonstrate biocompatible cholesterol-derivative microdroplet lasers via self-assembly to an onion-like radially-resonant photonic crystal structure.