Effect of cilia-induced surface velocity on cerebrospinal fluid exchange in the lateral ventricles
Effect of cilia-induced surface velocity on cerebrospinal fluid exchange in the lateral ventricles
复制标题
纤毛诱导的表面速度对侧脑室脑脊液交换的影响
DOI：
10.1098/rsif.2022.0321
复制
发表时间：
2022
影响因子：
3.9
通讯作者：
Imai Yohsuke
中科院分区：
文献类型：
--
作者：
Yoshida Haruki;Ishida Shunichi;Yamamoto Taiki;Ishikawa Takayuki;Nagata Yuichi;Takeuchi Kazuhito;Ueno Hironori;Imai Yohsuke
睫状体运动障碍已知会导致脑积水。脑脊髓液（CSF）流动的瞬时速度主要由动脉搏动决定，但纤毛功能障碍导致脑积水的原因尚不清楚。在这项研究中，我们研究了纤毛引起的表面速度对脑脊液流动的影响，使用计算流体动力学。使用医学成像数据构建了人体心室的几何模型。以脉络丛产生的CSF和纤毛诱导的表面速度作为心室壁的速度边界条件。我们开发了健康和减少纤毛运动模型的基础上纤毛诱导的速度在健康野生型和DPCD基因敲除小鼠的实验数据。结果表明，健康和纤毛运动减少模型之间的脑室内压几乎没有差异。此外，发现在纤毛运动减少的模型中，从脉络丛新产生的CSF没有扩散到侧脑室的前角和下角。这些结果表明，睫状体运动障碍可能会延迟脑脊液交换的前角和下角的侧脑室。
Ciliary motility disorders are known to cause hydrocephalus. The instantaneous velocity of cerebrospinal fluid (CSF) flow is dominated by artery pulsation, and it remains unclear why ciliary dysfunction results in hydrocephalus. In this study, we investigated the effects of cilia-induced surface velocity on CSF flow using computational fluid dynamics. A geometric model of the human ventricles was constructed using medical imaging data. The CSF produced by the choroid plexus and cilia-induced surface velocity were given as the velocity boundary conditions at the ventricular walls. We developed healthy and reduced cilia motility models based on experimental data of cilia-induced velocity in healthy wild-type and Dpcd-knockout mice. The results indicate that there is almost no difference in intraventricular pressure between healthy and reduced cilia motility models. Additionally, it was found that newly produced CSF from the choroid plexus did not spread to the anterior and inferior horns of the lateral ventricles in the reduced cilia motility model. These findings suggest that a ciliary motility disorder could delay CSF exchange in the anterior and inferior horns of the lateral ventricles.