Oligonucleotide-based theranostic nanoparticles in cancer therapy.
Oligonucleotide-based theranostic nanoparticles in cancer therapy.
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DOI：
10.2217/nnm-2016-0035
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发表时间：
2016-04
期刊：
影响因子：
5.5
通讯作者：
R. Shahbazi;B. Ozpolat;K. Ulubayram
中科院分区：
文献类型：
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作者：
R. Shahbazi;B. Ozpolat;K. Ulubayram
结合治疗和成像功能的治疗诊断方法在癌症纳米医学中显示出潜力。寡核苷酸如小干扰RNA和微小RNA是强大的治疗剂，已有效地用于治疗诊断系统中以对抗各种癌症。纳米颗粒用于通过被动或主动靶向将寡核苷酸递送到肿瘤中，同时保护寡核苷酸免受细胞外环境中的核酸酶的影响。量子点、氧化铁纳米颗粒和金纳米颗粒的使用以及用造影剂（如荧光染料、光学或磁性试剂和各种放射性同位素）进行标记，促进了肿瘤的早期检测和治疗效果的评估。在这篇文章中，我们回顾了治疗诊断学在癌症治疗和成像中的应用优势，特别关注以阿托伐他汀为基础的治疗。
Theranostic approaches, combining the functionality of both therapy and imaging, have shown potential in cancer nanomedicine. Oligonucleotides such as small interfering RNA and microRNA, which are powerful therapeutic agents, have been effectively employed in theranostic systems against various cancers. Nanoparticles are used to deliver oligonucleotides into tumors by passive or active targeting while protecting the oligonucleotides from nucleases in the extracellular environment. The use of quantum dots, iron oxide nanoparticles and gold nanoparticles and tagging with contrast agents, like fluorescent dyes, optical or magnetic agents and various radioisotopes, has facilitated early detection of tumors and evaluation of therapeutic efficacy. In this article, we review the advantages of theranostic applications in cancer therapy and imaging, with special attention to oligonucleotide-based therapeutics.