Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration.
Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration.
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DOI：
10.1007/s00401-006-0183-4
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发表时间：
2007-03
影响因子：
12.7
通讯作者：
Dickson DW
中科院分区：
文献类型：
--
作者：
Amador-Ortiz C;Ahmed Z;Zehr C;Dickson DW
海马硬化症（HS）的特征在于CA 1和下托中的选择性神经元损失和胶质增生，并且已经与几种疾病相关，包括阿尔茨海默病、额颞叶变性伴泛素免疫反应性包涵体（FTLD-U）、血管性痴呆和一些tau蛋白病。在某些情况下，HS与其他退行性病变无关。这种情况有时被称为HS痴呆（HSD）。HSD和HS在FTLD-U背景下的差异尚未得到系统研究。为此，8例HSD和10例HS与FTLD-U进行了研究与尼氏和高碘酸希夫染色，以评估神经元的损失和淀粉样小体，分别。切片用胶质细胞酸性蛋白、HLA-DR和突触素的抗体进行免疫染色，并用图像分析法测定每例CA 1和下托的免疫反应性。此外，用4-R tau抗体对切片进行免疫染色，以确定嗜银颗粒的存在。HSD与伴有FTLD-U的HS不同。具体来说，它在老年人中更常见，并且与更显著的神经元和突触丢失以及更大的反应性胶质增生相关。淀粉体在HSD中比在FTLD-U中更常见，但嗜银颗粒的频率没有差异。
Hippocampal sclerosis (HS) is characterized by selective neuronal loss and gliosis in CA1 and the subiculum and has been associated with several disorders, including Alzheimer’s disease, frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions (FTLD-U), vascular dementia and some tauopathies. In some cases, HS is not associated with other degenerative pathologies. Such cases are sometimes referred to as HS dementia (HSD). Differences between HSD and HS in the setting of FTLD-U have not been systematically investigated. To this end, eight cases of HSD and ten cases of HS associated with FTLD-U were studied with Nissl and periodic acid-Schiff stains to assess neuronal loss and corpora amylacea, respectively. Sections were immunostained with antibodies to glial fibrillary acidic protein, HLA-DR and synaptophysin and immunoreactivity was measured with image analysis in CA1 and the subiculum of each case. Additionally, sections were immunostained with antibodies to 4-R tau to determine the presence of argyrophilic grains. HSD was different from HS associated with FTLD-U. Specifically, it was more common in the elderly, and it was associated with more marked neuronal and synaptic loss and with greater reactive gliosis. Corpora amylacea tended to be more frequent in HSD than in FTLD-U, but there was no difference in frequency of argyrophilic grains.
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DOI：
10.1093/jnen/61.12.1040
发表时间：
2002-12-01
影响因子：
3.2
作者：
Ishizawa, T;Ko, LW;Dickson, DW
通讯作者：
Dickson, DW
影响因子：
--
作者：
Josephs, Keith A.;Whitwell, Jennifer L.;Dickson, Dennis W.
通讯作者：
Dickson, Dennis W.
影响因子：
9.9
作者：
Ala, TA;Beh, GO;Frey, WH
通讯作者：
Frey, WH
影响因子：
--
作者：
Josephs, KA;Parisi, JE;Dickson, DW
通讯作者：
Dickson, DW
影响因子：
--
作者：
Leverenz, JB;Agustin, CM;Larson, EB
通讯作者：
Larson, EB