EPIDEMIOLOGIC EVIDENCE ON COCAINE USE AND PANIC ATTACKS
EPIDEMIOLOGIC EVIDENCE ON COCAINE USE AND PANIC ATTACKS
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DOI：
10.1093/oxfordjournals.aje.a115166
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发表时间：
1989-03-01
影响因子：
5
通讯作者：
PETRONIS, KR
中科院分区：
文献类型：
--
作者：
ANTHONY, JC;TIEN, AY;PETRONIS, KR
有经验的吸毒者和临床医生报告说，可卡因会导致恐慌症发作。这一说法得到了关于该药物药理活性的实验室证据的支持。在这篇论文中，作者使用流行病学策略对20世纪80年代初5896名成年家庭居民的访谈数据进行了检验，这些居民在美国康涅狄格州纽黑文(美国)、马里兰州巴尔的摩(美国)、密苏里州圣路易斯(美国)、北卡罗来纳州达勒姆(美国)和加利福尼亚州洛杉矶(美国)进行了一项关于精神障碍的协作性多地点研究。在这个样本中，与在随访期间没有使用可卡因的受试者相比，在该样本中发现的可卡因使用者的恐慌症发作的风险更大。在对先前存在的精神疾病、酒精和大麻的使用以及恐慌症发作的可疑社会人口学风险因素进行统计调整后，可卡因与恐慌之间的关联仍然很强。在报告在随访期间没有使用大麻的可卡因使用者中，风险最大(估计相对风险=13.0，95%可信区间：2.24-75.8)。这项研究还确定了恐慌症发作的其他决定因素，包括性别、婚姻状况、就业状况、工作声望、严重抑郁和酗酒。
Experienced drug takers and clinicians report that cocaine causes panic attacks. This claim is supported by laboratory evidence on the pharmacologic activity of the drug. In this paper, the authors have used an epidemiologic strategy to examine the suspected cocaine-panic association, with interview data from 5,896 adult household residents sampled in the early 1980s and followed prospectively for a collaborative multisite study of mental disorders in five US metropolitan areas; New Haven, Connecticut (USA); Baltimore, Maryland (USA); St. Louis, Missouri (USA); Durham, North Carolina (USA); and Los Angeles, California (USA). The risk of panic attacks was observed to be greater for identified cocaine users in this sample, as compared with subjects who did not use cocaine during the follow-up interval. The cocaine-panic association remained strongly after statistical adjustment for preexisting psychiatric conditions, use of alcohol and marijuana, and suspected sociodemographic risk fctors for panic attacks. The risk was greatest among cocaine users who reported no marijuana use during the follow-up interval (estimated relative risk = 13.0, 95% confidence interval: 2.24-75.8). The study also identified other determinants for panic attack, including sex, marital status, employment status, job prestige, major depression, and heavy drinking.