Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells
Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells
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DOI：
10.1182/blood-2015-09-668251
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发表时间：
2016-06-16
期刊：
影响因子：
20.3
通讯作者：
Schultz, Kirk R.
中科院分区：
文献类型：
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作者：
Kariminia, Amina;Holtan, Shernan G.;Schultz, Kirk R.
慢性移植物抗宿主病（cGVHD）是同种异体血液和骨髓移植后最重要的长期并发症之一。cGVHD的诊断生物标志物是早期诊断所必需的，并可指导预后标志物的鉴定。尚未验证cGVHD生物标志物可用于临床实践。我们在2个独立的测试集（共36例）中评估了先前已知的标志物并对cGVHD生物标志物进行了基于发现的分析
Chronic graft-versus-host disease(cGVHD) remains one of the most significant long-term complications after allogeneic blood and marrow transplantation. Diagnostic biomarkers for cGVHD are needed for early diagnosis and may guide identification of prognostic markers. No cGVHD biomarker has yet been validated for use in clinical practice. We evaluated both previously known markers and performed discovery-based analysis for cGVHD biomarkers in a 2 independent test sets (total of 36 cases