The Effect of Stimulus Size on the Reliable Stimulus Range of Perimetry
The Effect of Stimulus Size on the Reliable Stimulus Range of Perimetry
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DOI：
10.1167/tvst.4.2.10
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发表时间：
2015-03-01
影响因子：
3
通讯作者：
Swanson, William H.
中科院分区：
文献类型：
--
作者：
Gardiner, Stuart K.;Demirel, Shaban;Swanson, William H.
目的：自动视野检查使用 3.5 log 单位 (35dB) 范围的刺激对比度来评估视野内的功能。使用“尺寸 III”刺激 (0.438)，由于视网膜神经节细胞反应饱和，在可用对比度最高 15dB 内呈现刺激可能不会增加青光眼受损位置的反应概率。本实验检查改为使用“大小 V”(1.728) 刺激的效果。方法：使用恒定刺激方法，在每个参与者的四个位置测量 35 名参与者（平均偏差 -20.9 至 -3.4 dB，年龄 52-87）每个刺激大小的圆形点刺激的亮度增量阈值。每个尺寸和位置都拟合了观看频率曲线，具有三个自由参数：平均值、标准差和渐近最大响应概率。这些用于估计每个参与者对 25% 的演示 (c25) 的反应的对比。结果：使用分段正交回归，观察到的 III 号刺激的最大反应概率在 c25 = 25.2 dB 时开始下降（自引导重采样的 95% 置信区间为 23.3-29.0 dB）。这种下降始于大小 V 刺激的类似对比度：c25 = 25.0dB (22.0-26.8 dB)。在两种刺激大小的灵敏度均高于这些分割点的位置中，大小 V 的 c25 平均比大小 III 的刺激高 5.6 dB。结论：刺激大小之间可靠刺激范围的下限没有显着差异。然而，当使用 V 号刺激时，更多位置仍处于可靠的刺激范围内。转化相关性：V 号刺激可以在青光眼疾病过程中进行可靠的临床测试。
Purpose: Automated perimetry uses a 3.5 log unit (35dB) range of stimulus contrasts to assess function within the visual field. Using 'Size III' stimuli (0.438), presenting stimuli within the highest 15dB of available contrast may not increase the response probability at locations damaged by glaucoma, due to retinal ganglion cell response saturation. This experiment examines the effect of instead using 'Size V' (1.728) stimuli.Methods: Luminance increment thresholds for circular spot stimuli of each stimulus size were measured in 35 participants (mean deviation -20.9 to -3.4 dB, ages 52-87) using the method of constant stimuli, at four locations per participant. Frequency-of-seeing curves were fit at each size and location, with three free parameters: mean, standard deviation, and asymptotic maximum response probability. These were used to estimate the contrasts to which each participant would respond on 25% of presentations (c25).Results: Using segmented orthogonal regression, the maximum observed response probabilities for size III stimuli began to decline at c25 = 25.2 dB (95% confidence interval 23.3-29.0 dB from bootstrap resampling). This decline started at similar contrast for the size V stimulus: c25 = 25.0dB (22.0-26.8 dB). Among locations at which the sensitivity was above these split-points for both stimulus sizes, c25 averaged 5.6 dB higher for size V than size III stimuli.Conclusions: The lower limit of the reliable stimulus range did not differ significantly between stimulus sizes. However, more locations remained within the reliable stimulus range when using the size V stimulus.Translational Relevance: Size V stimuli enable reliable clinical testing later into the glaucomatous disease process.