The effects of hyperventilation on axonal excitability parameters in patients with diabetes mellitus and polyneuropathy
The effects of hyperventilation on axonal excitability parameters in patients with diabetes mellitus and polyneuropathy
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DOI：
10.1016/j.diabres.2016.04.058
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发表时间：
2016-08-01
影响因子：
5.1
通讯作者：
Uysal, Hilmi
中科院分区：
文献类型：
--
作者：
Akca, Gokcen;Yerdelen, Deniz;Uysal, Hilmi
目的：我们旨在探讨糖尿病（DM）和多发性神经病（PNP）以及无 PNP 患者的轴突兴奋性参数。方法：我们使用 QTRAC 的短 TROND 方案测量 12 名健康受试者、14 名患有 PNP 的 DM 患者和 10 名无 PNP 的 DM 患者的轴突兴奋性参数（强度持续时间常数（SDTC）、流变碱等）。在健康受试者和糖尿病患者深度过度通气 20 分钟之前和之后执行短 TROND 方案。此外，在过度换气（HPV）之前和 HPV 20 分钟后记录静脉血 pH 值以及 O-2 和 CO2 分压。 HPV感染前后均进行“过度通气评分”评估。结果：HPV感染前PNP组和对照组的DM值比较，SDTC和潜伏期有统计学意义。比较 HPV 后的兴奋性参数值，结果显示对照组和无 PNP 的 DM 患者在 2.5 ms 时的 SDTC、流变碱和不应性发生了统计学显着变化。 HPV 导致合并 PNP 的 DM 患者的 SDTC 没有变化。结论：本研究结果表明，DM 患者和健康受试者对 HPV 的反应不同，与健康对照和无 PNP 的 DM 患者相比，pH 变化对糖尿病 PNP 的影响不同。 (C) 2016 Elsevier Ireland Ltd. 保留所有权利。
Aims: We aimed to explore axonal excitability parameters in patients with diabetes mellitus (DM) and polyneuropathy (PNP) as well as those without PNP.Methods: We used the short TROND protocol by QTRAC to measure axonal excitability parameters (strength-duration time constant (SDTC), rheobase, etc.) in 12 healthy subjects and 14 DM patients with PNP and 10 DM patients without PNP. The short TROND protocol was performed before and after 20 min of deep hyperventilation in healthy subjects and patients with DM. Also, venous blood pH and partial pressure of O-2 and CO2 were recorded before hyperventilation (HPV) and after 20 min of HPV. A "hyperventilation score" was evaluated before and after HPV.Results: When the values of DM with PNP group and control group before HPV were compared, SDTC and latency were statistically significant. Comparing the values of the excitability parameters after HPV showed statistically significant changes in the SDTC, rheobase, and refractoriness at 2.5 ms in controls and DM patients without PNP. HPV resulted in no changes in SDTC in DM patients with PNP.Conclusion: The results of this study suggest that patients with DM and healthy subjects have different responses to HPV, and pH changes have different effects on diabetic PNP compared with healthy controls and DM patients without PNP. (C) 2016 Elsevier Ireland Ltd. All rights reserved.