THE X-LINKED METHYLATED DNA-BINDING PROTEIN, MECP2, IS SUBJECT TO X-INACTIVATION IN THE MOUSE
THE X-LINKED METHYLATED DNA-BINDING PROTEIN, MECP2, IS SUBJECT TO X-INACTIVATION IN THE MOUSE
复制标题
DOI：
10.1007/bf00356163
复制
发表时间：
1995-08-01
期刊：
影响因子：
2.5
通讯作者：
DISTECHE, CM
中科院分区：
文献类型：
--
作者：
ADLER, DA;QUADERI, NA;DISTECHE, CM
在哺乳动物中，X连锁基因启动子区域的DNA甲基化与X失活的维持有关。甲基化DNA结合蛋白之一，MECP 2，其结合DNA中的甲基化碱基，由位于小鼠X染色体（Chr）上的基因（Mecp 2）编码。为了确定该基因是否从失活的X Chr表达，使用X-常染色体易位（T（X;16）16 H）系统，其中可以测定失活的X Chr上的Mecp 2等位基因的表达。这些实验的结果表明Mecp 2在小鼠中经历X失活。
DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2 that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whether this gene was expressed from the inactive X Chr, and X-autosome translocation (T(X;16)16H) system in which expression from the Mecp2 allele on the inactive X Chr could be assayed was used. Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse.