Target-Specific PET Probes for Neurodegenerative Disorders Related to Dementia
Target-Specific PET Probes for Neurodegenerative Disorders Related to Dementia
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DOI：
10.2967/jnumed.110.077164
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发表时间：
2010-09-01
影响因子：
9.3
通讯作者：
Nordberg, Agneta
中科院分区：
文献类型：
--
作者：
Kadir, Ahmadul;Nordberg, Agneta
痴呆症是一个非常普遍的问题，导致大量残疾和死亡，给个人、家庭和社会造成巨大损失。导致痴呆的 4 种最常见的神经退行性疾病——阿尔茨海默病、额颞叶痴呆、路易体痴呆和帕金森病痴呆——具有不同的潜在病因和发病机制。非常需要早期诊断标记物；因此，功能性脑成像可能有助于神经退行性疾病引起的痴呆的检测和鉴别诊断。 PET 等功能成像可以对功能性脑活动进行体内成像，显示脑血流量和脑葡萄糖代谢，并且 PET 可以对神经递质活动进行成像，包括胆碱能、多巴胺能和血清素能系统的活动。新型 PET 神经影像示踪剂正在开发中，用于检测淀粉样斑块和小胶质细胞活性等病理参数。分子成像的发展对于痴呆症的早期诊断、治疗患者的选择以及治疗的评估非常重要。
Dementia is a highly prevalent problem causing considerable disability and mortality and exacting great costs to individuals, their families, and society. The 4 most common neurodegenerative disorders that cause dementia-Alzheimer disease, frontotemporal dementia, dementia with Lewy bodies, and dementia in Parkinson disease-have different underlying etiologies and pathogenetic mechanisms. There is a great need for early diagnostic markers; functional brain imaging may therefore assist in the detection and differential diagnosis of dementia due to neurodegenerative diseases. Functional imaging such as PET allows in vivo imaging of functional brain activity indicating cerebral blood flow and cerebral glucose metabolism, and PET allows imaging of neurotransmitter activity, including that of the cholinergic, dopaminergic, and serotonergic systems. New PET neuroimaging tracers are being developed for detecting pathologic parameters such as amyloid plaque and microglial activity. The development of molecular imaging is important for early diagnosis of dementia, selection of patients for therapies, and evaluation of therapies.