Social Isolation and Cognitive Function in Later Life: A Systematic Review and Meta-Analysis.
Social Isolation and Cognitive Function in Later Life: A Systematic Review and Meta-Analysis.
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DOI：
10.3233/jad-180501
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Clare L
中科院分区：
文献类型：
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作者：
Evans IEM;Martyr A;Collins R;Brayne C;Clare L
有一些证据表明，社会孤立可能与晚年认知功能不佳有关。然而，研究结果并不一致，用于评估社会隔离的措施也存在很大差异。我们进行了系统回顾和荟萃分析，以调查社会孤立与晚年认知功能之间的关联。 PsycInfo、CINAHL、PubMed 和 AgeLine 进行了一项纵向研究，评估社会隔离（包括社交活动和社交网络）与认知功能（包括认知、记忆和执行功能的整体测量）之间的关系。进行了随机效应荟萃分析，以评估社会孤立测量与认知功能之间的总体关联。子分析调查了社会孤立的不同方面与认知功能的每项测量之间的关联。系统评价确定了 65 篇文章，荟萃分析纳入 51 篇文章。以高度参与社交活动和大型社交网络为特征的低水平社会孤立与更好的晚年认知功能相关（r = 0.054，95％CI：0.043，0.065）。亚组分析表明，社会孤立与整体认知功能、记忆和执行功能测量之间的关联相似，并且根据性别或随访年数没有差异。社会孤立的各个方面与晚年的认知功能有关。不同研究中测量社交活动和社交网络的方法存在很大差异，这可能导致报告结果的不一致。
There is some evidence to suggest that social isolation may be associated with poor cognitive function in later life. However, findings are inconsistent and there is wide variation in the measures used to assess social isolation. We conducted a systematic review and meta-analysis to investigate the association between social isolation and cognitive function in later life. A search for longitudinal studies assessing the relationship between aspects of social isolation (including social activity and social networks) and cognitive function (including global measures of cognition, memory, and executive function) was conducted in PsycInfo, CINAHL, PubMed, and AgeLine. A random effects meta-analysis was conducted to assess the overall association between measures of social isolation and cognitive function. Sub-analyses investigated the association between different aspects of social isolation and each of the measures of cognitive function. Sixty-five articles were identified by the systematic review and 51 articles were included in the meta-analysis. Low levels of social isolation characterized by high engagement in social activity and large social networks were associated with better late-life cognitive function (r = 0.054, 95% CI: 0.043, 0.065). Sub-analyses suggested that the association between social isolation and measures of global cognitive function, memory, and executive function were similar and there was no difference according to gender or number of years follow-up. Aspects of social isolation are associated with cognitive function in later life. There is wide variation in approaches to measuring social activity and social networks across studies which may contribute to inconsistencies in reported findings.