The role of Propionibacterium acnes in acne pathogenesis: facts and controversies
The role of Propionibacterium acnes in acne pathogenesis: facts and controversies
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DOI：
10.1016/j.clindermatol.2009.03.012
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发表时间：
2010-01-01
影响因子：
2.7
通讯作者：
Katsambas, Andreas D.
中科院分区：
文献类型：
--
作者：
Dessinioti, Clio;Katsambas, Andreas D.
自1896年首次提出痤疮病变中发现的痤疮丙酸杆菌是导致痤疮的原因以来，我们已经走过了漫长的道路。尽管一些证据表明P痤疮在痤疮中的直接作用，但P痤疮在痤疮发病机制中的作用仍存在争议。P痤疮在痤疮炎症期的诱导和维持中的重要性已经确立。新出现的数据表明，炎症事件发生在痤疮发展的最早阶段，这重新开启了关于这种微生物在粉刺形成和痤疮起始的潜在参与的辩论。(C) 2010爱思唯尔公司版权所有。
We have come a long way since 1896, when it was first suggested that Propionibacterium acnes, found in acne lesions, was the cause of acne. Although several lines of evidence suggest the direct role of P acnes in acne, the mechanism by which P acnes contributes to the pathogenesis of acne is debated. The importance of P acnes in the induction and maintenance of the inflammatory phase of acne has been established. Emerging data that inflammatory events occur in the very earliest stages of acne development have reopened the debate about the potential involvement of this microorganism in comedogenesis and acne initiation. (C) 2010 Elsevier Inc. All rights reserved.