Iron-coproporphyrin III is a natural cofactor in bacterioferritin from the anaerobic bacterium Desulfovibrio desulfuricans.
Iron-coproporphyrin III is a natural cofactor in bacterioferritin from the anaerobic bacterium Desulfovibrio desulfuricans.
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铁粪卟啉 III 是厌氧细菌脱硫弧菌 (Desulfovibrio desulfuricans) 细菌铁蛋白中的天然辅因子。
DOI：
10.1016/s0014-5793(00)01939-6
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发表时间：
2000
期刊：
影响因子：
3.5
通讯作者：
Teixeira,M
中科院分区：
文献类型：
--
作者：
Romão,CV;Louro,R;Timkovich,R;Lübben,M;Liu,MY;LeGall,J;Xavier,AV;Teixeira,M
最近从厌氧硫酸盐还原细菌脱硫弧菌ATCC 27774中分离到一种细菌铁蛋白[Romão等人。(2000)生物化学39,6841-6849]。尽管它的性质总体上与其他细菌亚铁素相似，但它含有一种与从需氧生物的细菌亚铁素中发现的血红素B完全不同的血红素。利用可见光和核磁共振光谱以及质谱分析，这种血红素现在被明确地鉴定为铁-共比例卟啉III，这是生物系统中第一个这样的假体基团的例子。这一意想不到的发现在厌氧菌，特别是硫酸盐还原细菌中的血红素生物合成途径的框架内进行了讨论。
A bacterioferritin was recently isolated from the anaerobic sulphate-reducing bacterium Desulfovibrio desulfuricans ATCC 27774 [Romão et al. (2000) Biochemistry 39, 6841–6849]. Although its properties are in general similar to those of the other bacterioferritins, it contains a haem quite distinct from the haem B, found in bacterioferritins from aerobic organisms. Using visible and NMR spectroscopies, as well as mass spectrometry analysis, the haem is now unambiguously identified as iron-coproporphyrin III, the first example of such a prosthetic group in a biological system. This unexpected finding is discussed in the framework of haem biosynthetic pathways in anaerobes and particularly in sulphate-reducing bacteria.