Luteinizing hormone receptor status and clinical, pathologic, and prognostic features in patients with breast carcinomas
Luteinizing hormone receptor status and clinical, pathologic, and prognostic features in patients with breast carcinomas
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DOI：
10.1002/cncr.11294
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发表时间：
2003-04-01
期刊：
影响因子：
6.2
通讯作者：
Milgrom, E
中科院分区：
文献类型：
--
作者：
Meduri, G;Charnaux, N;Milgrom, E
背景。已经确定怀孕可以预防乳腺癌，动物模型表明，人绒毛膜促性腺激素（hCG）通过抑制实验性乳腺癌的发生和发展来模拟这种作用。促黄体生成素(LH)/促绒毛膜促性腺激素受体（LHR）已在几种人乳腺癌细胞系和有限数量的乳腺癌活检标本中被表征。这些观察结果提示，促性腺激素可作为预防和治疗乳腺癌的一种手段。作者使用免疫细胞化学分析了160名患者的肿瘤，这些患者的随访时间中位数为2539天。使用每个肿瘤中18%免疫标记细胞的临界值，72%的肿瘤被确定为LHR阳性。lhr阳性肿瘤更常见于绝经前妇女，她们的肿瘤细胞分化更大，雌激素受体α状态阳性。浸润性小叶癌LHR阳性较浸润性导管癌多见。LHR状态与淋巴结浸润、肿瘤大小或孕激素受体状态无相关性。lhr阳性肿瘤患者的无转移生存期较长，但统计学意义不大（P = 0.07），这很可能是由于所研究患者的事件数量有限。相反，lhr阳性和lhr阴性肿瘤患者在局部无复发期的差异无统计学意义。LHR状态似乎部分与乳腺肿瘤的分化程度有关，证实了hCG对乳腺组织影响的实验证据。LHR的存在是一个很大程度上独立于其他临床和病理肿瘤特征的肿瘤特征。在未来，将LHR的存在与个体患者对hCG的可能治疗反应联系起来可能会引起人们的兴趣。
BACKGROUND. it has been established that pregnancy protects against breast carcinoma, and animal models have shown that human chorionic gonadotropin (hCG) mimics this effect by inhibiting the initiation and progression of experimental breast carcinoma. Luteinizing hormone (LH)/hCG receptors (LHR) have been characterized in several human breast carcinoma cell lines and in a limited number of breast carcinoma biopsy specimens. These observations led to the suggestion that hCG may be used as a means of prevention and possibly treatment in patients with breast carcinoma.METHODS. The authors used immunocytochemistry to analyze tumors from 160 patients who were followed for a median of 2539 days. Using a cut-off value of 18% immunolabeled cells in each tumor, 72% of tumors were identified as LHR positive. The LHR-positive tumors were found more frequently in premenopausal women, who had tumors with greater cell differentiation and positive estrogen receptor alpha status. Infiltrating lobular carcinomas were positive for LHR more frequently compared with infiltrating ductal carcinomas. There was no correlation between LHR status and lymph node invasion, tumor size, or progesterone receptor status.RESULTS. Patients with LHR-positive tumors had a longer metastasis free survival, although the statistical significance was slight (P = 0.07), most likely due to the limited number of events in the patients studied. Conversely, there was no difference between patients with LHR-positive or LHR-negative tumors in the local recurrence free interval.CONCLUSIONS. LHR status seems to be related in part to the degree of differentiation in breast tumors, confirming experimental evidence of the effect of hCG on mammary tissue. The presence of LHR is a tumor characteristic that largely is independent of other clinical and pathologic tumor features. It may be of interest in the future to correlate the presence of LHR with a possible therapeutic response in individual patients to hCG.