Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women
Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women
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DOI：
10.1016/j.diabres.2009.12.022
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发表时间：
2010-04-01
影响因子：
5.1
通讯作者：
Takayanagi, Ryoichi
中科院分区：
文献类型：
--
作者：
Ohnaka, Keizo;Kono, Suminori;Takayanagi, Ryoichi
目的：本研究的目的是在日本中老年男性和女性中检测血清胆红素（一种内源性抗氧化剂）与血清高敏C反应蛋白（hs-CRP）水平、HbA（1c）和2型糖尿病患病率之间的关系（n = 12，400）。采用协方差分析和Logistic回归分析估计hs-CRP和HbA（1c）的几何均数结果：hs-CRP和HbA（1c）的几何平均值随着血清胆红素浓度的增加而逐渐降低，男性和女性的hs-CRP和HbA（1c）的几何平均值随着血清胆红素浓度的增加而逐渐降低。校正hs-CRP后，血清胆红素和HbA（1c）之间的负相关性略有减弱，但仍保持高度显著性（男性趋势P = 0.0004，女性趋势P = 10（-5））。血清总胆红素最低至最高五分位数的糖尿病患病率的多变量校正比值比分别为1.00、1.00、0.73、0.80和0.73（趋势P = 0.002），未校正hs-CRP，1.00、1.04、0.76、0.86和0.79结论：较高浓度的血清胆红素可能有助于预防2型糖尿病的发生。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Aim: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA(1c), and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n = 12,400).Methods: Analysis of covariance and logistic regression analysis were used to estimate geometric means of hs-CRP and HbA(1c) and odds ratios of prevalent diabetes according to bilirubin concentrations, respectively, with statistical adjustment for behavioral factors and liver enzymes.Results: Geometric means of hs-CRP and HbA(1c) were progressively lower with increasing concentrations of serum bilirubin in men and women each. An inverse association between serum bilirubin and HbA(1c) was slightly attenuated after adjustment for hs-CRP, but still remained highly significant (trend P = 0.0004 in men and trend P = 10(-5) in women). Multivariate-adjusted odds ratios of prevalent diabetes for the lowest to highest quintiles of serum total bilirubin were 1.00, 1.00, 0.73, 0.80, and 0.73 (trend P = 0.002), without adjustment for hs-CRP, and 1.00, 1.04, 0.76, 0.86, and 0.79 (trend P = 0.01), with adjustment for hs-CRP.Conclusions: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes. (C) 2010 Elsevier Ireland Ltd. All rights reserved.