Impact of specific KRAS mutation in exon 2 on clinical outcome of chemotherapy- and radiotherapy-treated colorectal adenocarcinoma patients.
Impact of specific KRAS mutation in exon 2 on clinical outcome of chemotherapy- and radiotherapy-treated colorectal adenocarcinoma patients.
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DOI：
10.1007/s40291-014-0107-2
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发表时间：
2014-10
影响因子：
4
通讯作者：
Lewandowska, Marzena Anna
中科院分区：
文献类型：
--
作者：
Roszkowski, Krzysztof;Zurawski, Bogdan;Jozwicki, Wojciech;Basta, Pawel;Lewandowska, Marzena Anna
通过高通量技术获得的知识，用于肿瘤基因组测序或鉴定基因表达和甲基化特征，由于肿瘤发展和进展背景下的分子表征，具有临床应用价值。本研究旨在评估密码子12和13中特定KRAS突变对结直肠癌患者化疗和放疗临床结局的影响。共239例结直肠腺癌样本进行了组织学评价和DNA分离。KRAS密码子13突变的患者比KRAS密码子12突变的患者结局更差。此外，KRAS密码子12或13突变的病例与比野生型KRAS病例显著更高的死亡率相关，并且一些密码子12突变的KRAS患者的总生存期特别长。最后，术前放疗后手术比手术后化疗能更有效地提高总生存率。这一点应在进一步的研究中进行调查。所有接受放疗+手术治疗的患者均存活的事实再次将我们的注意力集中在术前放疗对结直肠癌患者预后的影响上。然而，该亚组中的患者数量太少，无法对此观察结果进行任何具体解释。相反，我们应该指出一个需要进一步调查的问题。
Knowledge obtained via high-throughput technologies, used for tumor genome sequencing or identifying gene expression and methylation signatures, is clinically applicable thanks to molecular characterization in the context of tumor development and progression. This study was conducted to assess the impact of specific KRAS mutation in codons 12 and 13 on clinical outcome of chemotherapy and radiotherapy in colorectal cancer patients. A total of 239 samples of colorectal adenocarcinoma underwent histological evaluation and DNA isolation. Patients with a mutation in KRAS codon 13 experienced worse outcome than those with a mutation in KRAS codon 12. Moreover, the cases of mutations in KRAS codons 12 or 13 were associated with a significantly higher mortality than the cases of wild-type KRAS, and some patients with KRAS mutated in codon 12 had an exceptionally long overall survival. Finally, primary preoperative radiation therapy followed by surgery significantly increased overall survival more efficiently than surgery followed by chemotherapy. This should be investigated in further studies. The fact that all patients treated with radiotherapy + surgery were alive, again focused our attention on the effect of preoperative radiation therapy on the prognosis for colorectal cancer patients. However, the number of patients in this subgroup is too small to allow any specific explanation for this observation. We should, rather, point out a problem for further investigation.
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KRAS密码子61、146和BRAF突变预测KRAS密码子12和13野生型转移性结直肠癌中对西妥昔单抗和伊立替康的抗性。
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
45.3
作者：
O'Connell, Michael J.;Lavery, Ian;Wolmark, Norman
通讯作者：
Wolmark, Norman
影响因子：
64.8
作者：
SEEBURG, PH;COLBY, WW;LEVINSON, AD
通讯作者：
LEVINSON, AD
影响因子：
3.6
作者：
Pietrantonio, Filippo;Perrone, Federica;de Braud, Filippo
通讯作者：
de Braud, Filippo
DOI：
10.1073/pnas.96.15.8681
发表时间：
1999-07-20
影响因子：
11.1
作者：
Toyota, M;Ahuja, N;Issa, JPJ
通讯作者：
Issa, JPJ