Novel factors contributing to the expression of latent inhibition.
Novel factors contributing to the expression of latent inhibition.
复制标题
有助于潜在抑制表达的新因素。
DOI：
10.1037//0735-7044.116.5.824
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发表时间：
2002
影响因子：
1.9
通讯作者：
Steinmetz,JosephE
中科院分区：
文献类型：
--
作者：
Katz,DonaldB;Rogers,RonaldF;Steinmetz,JosephE
通过两个实验研究了眨眼条件反射过程中潜伏抑制的行为和神经相关性。在实验1中，兔子（Oryctolagus cuniculus）条件后8天的音调条件刺激（CS）介绍或8天的上下文单独的经验。当一个相对强烈的（5 psi）的非条件刺激与CS配对时，在CS预暴露兔中观察到LI。在实验2中，兔子被给予0，4，或8天的CS预暴露或上下文单独的经验。监测了8天CS或环境暴露家兔的海马活性。LI效应仅见于CS预暴露4天的家兔，因此表明LI在很大程度上取决于上下文预暴露对照组的获取率。神经记录表明，海马是敏感的相对新奇的刺激和整体的背景下，无论是否暴露于刺激和上下文促进LI。
Behavioral and neural correlates of latent inhibition (LI) during eyeblink conditioning were studied in 2 experiments. In Experiment 1, rabbits (Oryctolagus cuniculus) were conditioned after 8 days of tone conditioned stimulus (CS) presentations or 8 days of context-alone experience. LI was seen in the CS-preexposed rabbits when a relatively intense (5 psi) airpuff unconditioned stimulus was paired with the CS. In Experiment 2, rabbits were given 0, 4, or 8 days of CS preexposures or context-alone experience. Hippocampal activity was monitored from the 8-day CS-or context-exposure rabbits. The LI effect was seen only in rabbits given 4 days of CS preexposure, thus suggesting that LI depended largely on the rate of acquisition in the context-preexposed control group. The neural recordings showed that the hippocampus was sensitive to the relative novelty of the stimuli and the overall context, regardless of whether exposure to stimuli and context promoted LI.