On the mechanism of asymmetric nucleophilic ring-opening of epoxides catalyzed by (salen)Cr-III complexes
On the mechanism of asymmetric nucleophilic ring-opening of epoxides catalyzed by (salen)Cr-III complexes
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DOI：
10.1021/ja962600x
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发表时间：
1996-11-06
影响因子：
15
通讯作者：
Jacobsen, EN
中科院分区：
文献类型：
--
作者：
Hansen, KB;Leighton, JL;Jacobsen, EN
亲核试剂和亲电试剂之间的对映选择性催化反应是合成的兴趣，因为这样的过程可以提供有价值的手性材料的实际访问。虽然有效的催化剂对映体选择性亲核加成简单的亲电体，如羰基化合物，1亚胺，2和epoxides3已在过去的十年中开发，在许多情况下，详细的机械理解，这些系统是如何运作的是缺乏。因此，合理开发新催化剂或改进现有催化剂的能力仍然有限。
Enantioselective catalysis of reactions between nucleophiles and electrophiles is of synthetic interest since such processes can provide practical access to valuable chiral materials. Although effective catalysts for enantioselective nucleophilic additions to simple electrophiles such as carbonyl compounds, 1 imines, 2 and epoxides3 have been developed over the past decade, in many cases a detailed mechanistic understanding of how these systems function is lacking. As a result, the ability to rationally develop new catalysts or improve existing ones remains limited.