Trimester-Specific Association of Maternal Exposure to Fine Particulate Matter and its Components With Birth and Placental Weight in Japan
Trimester-Specific Association of Maternal Exposure to Fine Particulate Matter and its Components With Birth and Placental Weight in Japan
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DOI：
10.1097/jom.0000000000002254
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发表时间：
2021-05
影响因子：
3.2
通讯作者：
Yuki Takeda;T. Michikawa;S. Morokuma;S. Yamazaki;Kazushige Nakahara;A. Yoshino;S. Sugata;A. Takami;S. Saito;J. Hoshi;Kiyoko Kato;H. Nitta;Y. Nishiwaki
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文献类型：
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作者：
Yuki Takeda;T. Michikawa;S. Morokuma;S. Yamazaki;Kazushige Nakahara;A. Yoshino;S. Sugata;A. Takami;S. Saito;J. Hoshi;Kiyoko Kato;H. Nitta;Y. Nishiwaki
补充数字内容可在文本目标：我们调查了暴露于PM2.5及其成分的妊娠期与出生和胎盘重量以及胎儿胎盘重量比相关。该研究包括2013年至2015年期间在东京23个病房内分娩单胎足月分娩的63，990名女性。每天，我们都用过滤器收集微粒，并分析它们的化学成分，包括碳和离子。每种污染物的三个月特定暴露量是根据平均日浓度估计的。结果如下：在妊娠晚期，硫酸盐暴露往往与出生体重呈负相关，胎盘重量下降（最高与最低五分位数组的差异=-6.7 g，95%置信区间=-12.5至0.9）。对于胎儿胎盘重量比，没有相关性。结论：妊娠晚期硫酸盐暴露可能会降低出生体重，特别是胎盘重量。
Supplemental Digital Content is available in the text Objective: We investigated which trimester of exposure to PM2.5 and its components was associated with birth and placental weight, and the fetoplacental weight ratio. Methods: The study included 63,990 women who delivered singleton term births within 23 Tokyo wards between 2013 and 2015. Each day, we collected fine particles on a filter, and analyzed their chemical constituents, including carbons and ions. Trimester-specific exposure to each pollutant was estimated based on the average daily concentrations. Results: Over the third trimester, sulfate exposure tended to be inversely associated with birth weight, and decreased placental weight (difference for highest vs lowest quintile groups = −6.7 g, 95% confidence interval = −12.5 to −0.9). For fetoplacental weight ratio, there was no relationship. Conclusions: Sulfate exposure over the third trimester may reduce birth weight, particularly placental weight.