Effects of dexmedetomidine on contractility, relaxation, and intracellular calcium transients of isolated ventricular myocardium.
Effects of dexmedetomidine on contractility, relaxation, and intracellular calcium transients of isolated ventricular myocardium.
复制标题
右美托咪定对离体心室心肌的收缩性、舒张性和细胞内钙瞬变的影响。
DOI：
10.1097/00000542-199011000-00020
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发表时间：
1990
期刊：
影响因子：
8.8
通讯作者：
Housmans,PR
中科院分区：
文献类型：
--
作者：
Housmans,PR
高选择性α 2-肾上腺素能受体激动剂右美托咪定对离体心室肌的收缩性、舒张性和细胞内Ca 2+瞬变的影响在利血平化雪貂获得的离体右心室乳头肌中进行了研究。右美托咪定（10（-10）-10（-5）M）未改变等长、等张和零负荷钳夹抽搐的振幅和时间变量，但在10（-5）M时最大等张舒张率略有增加。右美托咪定（10（-8）-10（-5）M）未引起水母发光蛋白检测到的细胞内Ca 2+瞬变变化。这些结果表明，右美托咪定无内在心肌收缩作用。
The effects of the highly selective alpha 2-adrenoceptor agonist dexmedetomidine on contractility, relaxation, and the intracellular Ca2+ transients of isolated ventricular myocardium were studied in isolated right ventricular papillary muscles obtained from reserpinized ferrets. Dexmedetomidine (10 (-10)-10 (-5) M) did not alter amplitude and time variables of isometric, isotonic and zero-load-clamped twitches, except for a slight increase in maximal isotonic relaxation rate at 10 (-5) M. Dexmedetomidine (10 (-8)-10 (-5) M) caused no changes in the intracellular Ca2+ transient detected with aequorin. These results suggest that dexmedetomidine has no intrinsic myocardial contractile effects.