MACROPHAGES WITHIN THE HUMAN ADRENAL-GLAND
MACROPHAGES WITHIN THE HUMAN ADRENAL-GLAND
复制标题
DOI：
10.1007/bf00414161
复制
发表时间：
1994-11-01
影响因子：
3.6
通讯作者：
SCHERBAUM, WA
中科院分区：
文献类型：
--
作者：
GONZALEZHERNANDEZ, JA;BORNSTEIN, SR;SCHERBAUM, WA
越来越多的证据表明巨噬细胞可能在免疫-肾上腺相互作用中发挥重要作用。然而，关于人肾上腺内巨噬细胞系统的数据很少。在这项研究中，我们使用单克隆抗体研究了人肾上腺巨噬细胞的密度、分布和表型。巨噬细胞分布于肾上腺的所有区域。这些细胞表现出吞噬巨噬细胞区室的表型（CD11c+、KiM8+）。在超微结构水平上，巨噬细胞经常附着在内皮细胞上，但也与皮质细胞和嗜铬细胞直接接触。这项研究揭示了巨噬细胞在局部免疫-神经内分泌轴中可能发挥作用的细胞基础。
There is increasing evidence for an immune-adrenal interaction in which macrophages may play an important role. However, few data are available with respect to a human intra-adrenal macrophage system. In this study, we have investigated the density, distribution and phenotype of human adrenal macrophages using monoclonal antibodies. Macrophages are localized in all zones of the adrenal gland. These cells exhibit the phenotype of the phagocytotic macrophage compartment (CD11c+, KiM8+). At the ultrastructural level, macrophages are frequently attached to the endothelial walt, but also lie in direct contact with cortical and chromaffin cells. This investigation reveals the cellular basis for the possible role of macrophages in the local immune-neuroendocrine axis.