Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function.
Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function.
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DOI：
10.1017/s1092852915000425
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发表时间：
2016-04
期刊：
影响因子：
3.3
通讯作者：
Sanchez C
中科院分区：
文献类型：
--
作者：
Dale E;Pehrson AL;Jeyarajah T;Li Y;Leiser SC;Smagin G;Olsen CK;Sanchez C
海马体在情绪和认知处理中发挥着重要作用，这两个区域在重度抑郁症 (MDD) 患者中都会受到影响。广泛的临床前研究以及血清素 (5-HT) 神经传递调节在选择性血清素再摄取抑制剂 (SSRI) 的治疗效果中发挥关键作用的观点支持了 5-HT 在正常和疾病样条件下对海马功能很重要的观点。海马体由血清素能纤维密集支配，大多数 5-HT 受体亚型都在那里表达。此外，海马细胞通常共表达多种 5-HT 受体亚型，这些亚型可以对细胞功能产生互补或相反的影响，从而增加 5-HT 神经传递的复杂性。在这里，我们回顾了目前关于 5-HT 如何通过其各种受体亚型调节啮齿动物海马输出和海马锥体细胞活性的知识。此外，我们还讨论了 5-HT 调节与啮齿类动物认知处理的相关性，以及这些结果对 MDD 患者可能的临床意义。最后，我们从临床前和临床角度回顾了 SSRI 和沃替西汀（一种具有多模式活性的抗抑郁药）如何影响海马功能（包括认知处理）的数据。
The hippocampus plays an important role in emotional and cognitive processing, and both of these domains are affected in patients with major depressive disorder (MDD). Extensive preclinical research and the notion that modulation of serotonin (5-HT) neurotransmission plays a key role in the therapeutic efficacy of selective serotonin reuptake inhibitors (SSRIs) support the view that 5-HT is important for hippocampal function in normal and disease-like conditions. The hippocampus is densely innervated by serotonergic fibers, and the majority of 5-HT receptor subtypes are expressed there. Furthermore, hippocampal cells often co-express multiple 5-HT receptor subtypes that can have either complementary or opposing effects on cell function, adding to the complexity of 5-HT neurotransmission. Here we review the current knowledge of how 5-HT, through its various receptor subtypes, modulates hippocampal output and the activity of hippocampal pyramidal cells in rodents. In addition, we discuss the relevance of 5-HT modulation for cognitive processing in rodents and possible clinical implications of these results in patients with MDD. Finally, we review the data on how SSRIs and vortioxetine, an antidepressant with multimodal activity, affect hippocampal function, including cognitive processing, from both a preclinical and clinical perspective.