Mixing with microwaves: solvent-free and catalyst-free synthesis of pyrazoles and diazepines
Mixing with microwaves: solvent-free and catalyst-free synthesis of pyrazoles and diazepines
复制标题
DOI：
10.1016/j.tetlet.2013.01.029
复制
发表时间：
2013-03-20
影响因子：
1.8
通讯作者：
Leazer, John
中科院分区：
文献类型：
--
作者：
Vaddula, Buchi Reddy;Varma, Rajender S.;Leazer, John
肼/酰肼和二胺与1，3-二酮/β-酮酯的简单和容易的缩合导致以高产率制备吡唑和二氮杂卓。这种环保的方案通过微波加热加速，并且在没有任何反应溶剂或催化剂的情况下在短短5分钟内有效地进行。
A simple and facile condensation of hydrazines/hydrazides and diamines with 1,3-diketones/beta-ketoester leads to the preparation of pyrazoles and diazepines in high yields. This eco-friendly protocol is accelerated by microwave heating and efficiently carried out without any reaction solvent or catalyst in as little as 5 min. Published by Elsevier Ltd.