The Risk for Medial Arterial Calcification in CKD
The Risk for Medial Arterial Calcification in CKD
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DOI：
10.2215/cjn.06490711
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发表时间：
2012-02-01
影响因子：
9.8
通讯作者：
O'Neil, W. Charles
中科院分区：
文献类型：
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作者：
Abou Hassan, Nada;D'Orsi, Ellen T.;O'Neil, W. Charles
背景和目的慢性肾脏病（CKD）是中动脉钙化的危险因素，但这种危险开始的CKD阶段尚不清楚。由于乳腺动脉钙化（BAG）是广泛性中膜动脉钙化的标志物，因此使用乳房X线摄影来检测不同CKD分期的女性中膜动脉钙化。设计、设置、参与者和测量这是一项回顾性横断面研究，研究对象为年龄和糖尿病相匹配的CKD患者和非CKD患者，并从2006-2011年获得的乳房X线摄影中确定。BAG评分为存在或不存在每visualinspection.Results共146例女性3期CKD和54例4/5期CKD被确定。确定了另外21例ESRD患者，并将其添加到先前的71例患者队列中。CKD 3、CKD 4和ESRD的平均年龄分别为64岁、63岁和59岁。每组中有一半人患有糖尿病。与对照组相比，CKD 3级、CKD 4级和ESRD中BAG的比值比分别为1.44（95%置信区间[CI]，0.82-2.53）、2.69（95% CI，1.14-6.33）和7.19（95% CI，3.77-13.7），且不随糖尿病状态或种族而异。在多因素Logistic模型中，年龄（P
Background and objectives CKD is a risk factor for medial artery calcification, but the CKD stage at which this risk begins is unknown. Because breast arterial calcification (BAG) is a marker of generalized medial arterial calcification, mammography was used to detect medial arterial calcification in women with different CKD stages.Design, setting, participants, & measurements This was a retrospective, cross-sectional study of women with and without CKD matched for age and diabetes and identified from mammograms obtained in 2006-2011. BAG was scored as present or absent per visual inspection.Results A total of 146 women with stage 3 CKD and 54 with stage 4/5 CKD were identified. An additional 21 patients with ESRD were identified and added to a previous cohort of 71 patients. Mean age was 64 years for CKD 3, 63 for CKD 4, and 59 for ESRD. Half of each group had diabetes. Compared with controls, the odds ratios for BAG were 1.44 in CKD 3 (95% confidence interval [CI], 0.82-2.53), 2.69 in CKD 4 (95% Cl, 1.14-6.33), and 7.19 in ESRD (95% CI, 3.77-13.7) and did not differ with diabetic status or race. In a multivariable logistic model, age (P