Gold nanorods core/AgPt alloy nanodots shell: A novel potent antibacterial nanostructure
Gold nanorods core/AgPt alloy nanodots shell: A novel potent antibacterial nanostructure
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金纳米棒核/AgPt合金纳米点壳：一种新型的有效抗菌纳米结构
DOI：
10.1007/s12274-013-0360-4
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发表时间：
2013-10-01
期刊：
影响因子：
9.9
通讯作者：
Wu, Xiaochun
中科院分区：
文献类型：
--
作者：
Hu, Xiaona;Zhao, Yuyun;Wu, Xiaochun
针对目前银纳米粒子（Ag NPs）在抗菌性能方面存在的问题，我们设计了一种新型的三金属核/壳纳米结构，即在金纳米棒上外延生长AgPt合金纳米点（Au@PtAg NRs）作为潜在的抗菌剂。大肠杆菌（Escherichia coli，E.大肠杆菌）和金黄色葡萄球菌（S.金黄色葡萄球菌）进行了研究。抗菌活性具有明显的组成依赖性。当合金壳中的Ag分数增加到80%时，抗菌活性逐渐增加，证明了调节该活性的灵活方式。当含银量为80%时，抗菌活性优于纯银壳。抗菌能力的提高主要是由于点形态导致银在壳体表面的高暴露。因此，我们表明，形成合金是一种有效的方法，以提高抗菌活性，同时保持高的化学稳定性的银基纳米材料。此外，由于在近红外（NIR）光谱区的可调局部表面等离子体响应，使用光的抗菌活性，如光热杀伤和光触发的银离子释放的额外控制是预期的。作为示范，通过利用纳米结构的NIR光热效应显示出高度增强的抗菌活性。我们的研究结果表明，这种定制的纳米结构将在未来对抗细菌的斗争中发挥作用，包括多药耐药性日益严重的挑战。
In the light of the current problems of silver nanoparticles (Ag NPs) in terms of antibacterial performance, we have designed a novel trimetallic core/shell nanostructure with AgPt alloy nanodots epitaxially grown on gold nanorods (Au@PtAg NRs) as a potential antibacterial agent. BothEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus) were studied. The antibacterial activity exhibits an obvious composition-dependence. On increasing the Ag fraction in the alloy shell up to 80%, the antibacterial activity gradually increases, demonstrating a flexible way to tune this activity. At 80% Ag, the antibacterial activity is better than that of a pure Ag shell. The improved antibacterial ability mainly results from the high exposure of silver on the shell surface due to the dot morphology. We thus demonstrate that forming alloys is an effective way to improve antibacterial activity while retaining high chemical stability for Ag-based nanomaterials. Furthermore, due to the tunable localized surface plasmonic response in the near-infrared (NIR) spectral region, additional control over antibacterial activity using light—such as photothermal killing and phototriggered silver ion release—is expected. As a demonstration, highly enhanced antibacterial activity is shown by utilizing the NIR photothermal effect of the nanostructures. Our results indicate that such tailored nanostructures will find a role in the future fight against bacteria, including the challenge of the increasing severity of multidrug resistance.