Systemic and eosinophilic lesions in rats with spontaneous eosinophilia (mes rats)
Systemic and eosinophilic lesions in rats with spontaneous eosinophilia (mes rats)
复制标题
DOI：
10.1354/vp.38-3-346
复制
发表时间：
2001-05-01
影响因子：
2.4
通讯作者：
Matsumoto, K
中科院分区：
文献类型：
--
作者：
Muto, S;Hayashi, M;Matsumoto, K
mes大鼠来自具有自发性嗜酸性粒细胞增多症的大鼠近交突变群体。为探讨mes大鼠的发病机制，对76只数周龄mes大鼠进行了组织病理学和血液学检查。组织嗜酸性粒细胞增多症在8周龄时发展，血液嗜酸性粒细胞为500个细胞/微升或更多。随后，随着年龄的增长，嗜酸性粒细胞增多，脾嗜酸性粒细胞和红细胞同时出现。许多炎性病变在10周龄后诱发，此时血液嗜酸性粒细胞达到每微升1，000个细胞或更多。10周龄后，分别在47只大鼠中的44只（94%）和47只大鼠中的31只（66%）中观察到胃肠炎和肠系膜淋巴结炎。12周龄后，39只大鼠中有19只（49%）发现了随年龄增长而恶化的主动脉炎。在4只大鼠中发现肝纤维化，表现出严重的嗜酸性粒细胞增多和贫血。这些结果与人类和其他动物的嗜酸性粒细胞增多综合征的特征相当。
The mes rat is from an inbred mutant colony of rats with spontaneous eosinophilia. In order to investigate the pathogenesis of the mes rat, the histopathology and hematology for 76 mes rats were examined at several weeks of age. Tissue eosinophilia developed at 8 weeks of age when the blood eosinophil was 500 cells per microliter or more. Subsequently, eosinophilia progressed with age, and splenic eosinophilopoiesis and erythropoiesis appeared simultaneously. Many inflammatory lesions were induced after 10 weeks of age when the blood eosinophils became 1,000 cells per microliter or more. Gastroenteritis and mesenteric lymphadenitis were seen in 44 of 47 (94%) and 31 of 47 (66%) rats, respectively, after 10 weeks of age. Aortitis that deteriorated with age was found in 19 of 39 (49%) rats after 12 weeks of age. Hepatic fibrosis was found in four rats that exhibited severe eosinophilia and anemia. These results are comparable to the features of a hypereosinophilic syndrome in humans and other animals.