The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
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DOI：
10.1086/380911
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发表时间：
2004-01-01
影响因子：
9.8
通讯作者：
Kalaydjieva, L
中科院分区：
文献类型：
--
作者：
Zhivotovsky, LA;Underhill, PA;Kalaydjieva, L
我们估计平均每25年Y染色体短串联重复序列基因座的有效突变率为6.9x10(-4)，跨基因座的标准偏差为5.7x10(-4)，使用有记录的短期病史的人群中由独特事件多态定义的染色体单倍组内微卫星变异的数据，以及Y染色体和各种常染色体基因座的全球人群的比较数据。该值用于估计非洲班图扩张的时间、波利尼西亚人(毛利人、库克岛人和萨摩亚人)的分化以及来自保加利亚的吉普赛人的起源。
We estimate an effective mutation rate at an average Y chromosome short-tandem repeat locus as 6.9 x 10(-4) per 25 years, with a standard deviation across loci of 5.7 x 10(-4), using data on microsatellite variation within chromosome haplogroups defined by unique-event polymorphisms in populations with documented short-term histories, as well as comparative data on worldwide populations at both the Y chromosome and various autosomal loci. This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria.