Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal.
Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal.
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DOI：
10.3390/nu8060375
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发表时间：
2016-06-22
期刊：
影响因子：
5.9
通讯作者：
Strand TA
中科院分区：
文献类型：
--
作者：
Chandyo RK;Ulak M;Sommerfelt H;Schneede J;Ueland PM;Strand TA
钴胺素和叶酸对育龄妇女尤其重要，因为它们在胎儿生长发育中无处不在。尼泊尔缺乏以人群为基础的钴胺素和叶酸状况的数据，该国的饮食主要是素食。该研究的目的是调查钴胺素和叶酸的摄入量和状况，并探讨其与社会人口统计学、人体测量学、贫血和饮食习惯的关系。在随机选择地理集群后，我们收集了500名非孕妇的血液样本，并从379名妇女的亚样本中收集了24小时饮食回忆和食物频率问卷。20%的女性在被召回的日子里没有食用任何含有钴胺素的食物，72%的女性营养钴胺素摄入量<1 μg/天。84%的女性钴胺素摄入量低于估计的平均需求量（EAR） （<2 μg/天）。相比之下，只有12%的女性每天叶酸摄入量低于100 μg，而62%的女性每天叶酸摄入量在100至320 μg之间。42%的女性血浆钴胺素水平较低（<150 pmol/L），其中大多数（88%）也有甲基丙二酸水平升高。我们的研究结果表明，营养钴胺素缺乏症的患病率很高，而叶酸缺乏症并不常见。
Cobalamin and folate are especially important for women of childbearing age due to their ubiquitous role in fetal growth and development. Population-based data on cobalamin and folate status are lacking from Nepal, where diets are mostly vegetarian. The objectives of the study were to investigate cobalamin and folate intake and status, and to explore associations with socio-demographics, anthropometrics, anemia, and dietary habits. Following a random selection of geographical clusters, we collected blood samples from 500 non-pregnant women and 24-h dietary recalls and food frequency questionnaires from a subsample of 379 women. Twenty percent of the women did not consume any food containing cobalamin during the days recalled, and in 72% nutritional cobalamin intake was <1 μg/day. Eighty-four percent of the women had cobalamin intake lower than the estimated average requirement (EAR) (<2 μg/day). In contrast, only 12% of the women had a folate intake less than 100 μg per day, whereas 62% had intake between 100 and 320 μg. Low plasma cobalamin (<150 pmol/L) was found in 42% of the women, most of whom (88%) also had elevated levels of methylmalonic acid. Our results indicated a high prevalence of nutritional cobalamin deficiency, while folate deficiency was uncommon.