CHANGES IN THE CONCENTRATIONS OF SERUM IGG, IGA AND IGM OF SOWS THROUGHOUT THE REPRODUCTIVE-CYCLE
CHANGES IN THE CONCENTRATIONS OF SERUM IGG, IGA AND IGM OF SOWS THROUGHOUT THE REPRODUCTIVE-CYCLE
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DOI：
10.1016/0165-2427(85)90023-6
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发表时间：
1985-12-01
影响因子：
1.8
通讯作者：
BUTLER, JE
中科院分区：
文献类型：
--
作者：
KLOBASA, F;HABE, F;BUTLER, JE
对3855头母猪(妊娠母猪3208头，哺乳期母猪647头)在同一时间点的血清进行了免疫球蛋白G、免疫球蛋白M和免疫球蛋白A的测定。这一实验设计允许研究生殖周期中血清免疫球蛋白的变化，而不受季节性影响的偏差。这三种免疫球蛋白的浓度在生殖周期中独立变化。血清Ig M和Ig G水平在妊娠14~17周开始呈进行性下降。在哺乳开始时，血清免疫球蛋白水平逐渐升高，而免疫球蛋白M水平继续下降，后者在哺乳第三周达到最低水平。与免疫球蛋白和免疫球蛋白相比，血清免疫球蛋白A水平在妊娠14-17周期间升高了35%，并在整个哺乳期持续升高，在哺乳第三周达到最高水平，此时的血清免疫球蛋白A浓度是妊娠前13周的两倍。这些研究的结果根据血清免疫球蛋白浓度将生殖周期分为四个阶段：(1)妊娠1-4周；(2)妊娠5-13周；(3)怀孕14-17周；(4)哺乳期。
The concentrations of IgG, IgM and IgA in sera collected from 3855 sows (3208 pregnant and 647 lactating) at a single time point were determined. This experimental design allowed changes in serum immunoglobulin over the reproductive cycle to be studied without bias from seasonal influence. The concentrations of the three immunoglobulins changed independently during the reproductive cycle. Serum levels of IgM and IgG began a progressive postpartal decline during the 14th-17th week of gestation. At the onset of lactation serum IgG levels progressively increased while IgM levels continued to decline, the latter reaching their lowest level during the third week of lactation. In contrast to IgM and IgG, serum IgA levels increased 35% during weeks 14-17 of gestation and continued to increase throughout lactation, reaching their highest serum levels in the third week of lactation; the serum IgA concentration at this time was twice that observed during the first 13 weeks of gestation. Results of these studies allowed the reproductive cycle to be classified into four phases on the basis of serum immunoglobulin concentrations: (1) weeks 1-4 of gestation; (2) weeks 5-13 of gestation; (3) weeks 14-17 of gestation and (4) lactation.