Extra O2 consumption attributable to NADH2 during maximum lactate oxidation in the heart.
Extra O2 consumption attributable to NADH2 during maximum lactate oxidation in the heart.
复制标题
在心脏最大乳酸氧化期间，NADH2 导致额外的 O2 消耗。
DOI：
10.1016/0006-291x(78)90661-7
复制
发表时间：
1978
影响因子：
3.1
通讯作者：
W. R. Sandel
中科院分区：
文献类型：
--
作者：
P. Molé;P. V. Handel;W. R. Sandel
The lactate/pyruvate oxidation (Qo2) ratio was 1.21 ± 0.04 for heart homogenates as compared to 0.92 ± 0.05 for white quadriceps muscle homogenates during state 3 respiration. The extra lactate Qo2could be accounted for by the oxidation of additional NADH2from lactate, assuming the oxidation of 12 H+/lactate and 10 H+/pyruvate. A high correlation of 0.92 was observed between extra lactate Qo2and activity of heart-type LDH isozyme. This finding and the mitochondrial location of heart-type isozyme (1) suggests the extra lactate Qo2in heart homogenates could represent the oxidation of NADH2formed from lactate by the mitochondria.
