Potential therapy strategy: targeting mitochondrial dysfunction in sepsis.
Potential therapy strategy: targeting mitochondrial dysfunction in sepsis.
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潜在的治疗策略：针对脓毒症中的线粒体功能障碍
DOI：
10.1186/s40779-018-0187-0
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发表时间：
2018-11-26
影响因子：
21.1
通讯作者：
Yao YM
中科院分区：
文献类型：
--
作者：
Zhang H;Feng YW;Yao YM
最近，脓毒症的定义被认为是由宿主对感染反应失调引起的危及生命的器官功能障碍。重症患者常出现无法纠正的低血压或高乳酸血症，定义为感染性休克。新的定义强调宿主反应失调和多器官功能障碍，部分归因于能量危机和氧化应激引起的代谢紊乱。线粒体是一种细胞器，被认为是能量产生的中心，线粒体损伤或功能障碍通常在脓毒性环境中引起，是导致预后不良的主要因素。在目前的审查，我们确定主要的线粒体疾病从形态到功能败血症。下面，根据积累的证据，介绍几种监测线粒体功能的临床或临床前检测方法，这是靶向调节线粒体功能的特异性治疗的第一步。因此，各种用于调节线粒体酶活性和促进生物发生的试剂已经被记录下来，其中线粒体靶向阳离子、tpp偶联抗氧化剂是未来试验和临床治疗中最有价值的，因为它们可能利用与脓毒性并发症相关的预后。
Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe patients always present with uncorrectable hypotension or hyperlactacidemia, which is defined as septic shock. The new definition emphasizes dysregulation of the host response and multiple organ dysfunction, which is partially attributed to metabolic disorders induced by energy crisis and oxidative stress. Mitochondria are a cellular organelle that are well known as the center of energy production, and mitochondrial damage or dysfunction is commonly induced in septic settings and is a predominant factor leading to a worse prognosis. In the present review, we determine the major mitochondrial disorders from morphology to functions in sepsis. In the following, several clinical or pre-clinical assays for monitoring mitochondrial function are demonstrated according to accumulated evidence, which is the first step of specific therapy targeting to modulate mitochondrial function. Accordingly, various reagents used for regulating mitochondrial enzyme activities and promoting biogenesis have been documented, among which mitochondria-targeted cation, TPP-conjugated antioxidants are the most valuable for future trials and clinical treatment to improve mitochondrial function as they may take advantage of the prognosis associated with septic complications.
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影响因子：
3.7
作者：
Chida J;Ono R;Yamane K;Hiyoshi M;Nishimura M;Onodera M;Nakataki E;Shichijo K;Matushita M;Kido H
通讯作者：
Kido H
影响因子：
3.1
作者：
Alvarez, Silvia;Evelson, Pablo A.
通讯作者：
Evelson, Pablo A.
影响因子：
7.4
作者：
Alvarez, S;Boveris, A
通讯作者：
Boveris, A
DOI：
10.1152/ajpregu.00432.2003
发表时间：
2004-03-01
影响因子：
2.8
作者：
Brealey, D;Karyampudi, S;Singer, M
通讯作者：
Singer, M
DOI：
10.1097/00005373-199703000-00023
发表时间：
1997-03-01
影响因子：
--
作者：
Cairns, CB;Moore, FA;Moore, EE
通讯作者：
Moore, EE