Gamma and beta frequency oscillations in response to novel auditory stimuli:: A comparison of human electroencephalogram (EEG) data with in vitro models
Gamma and beta frequency oscillations in response to novel auditory stimuli:: A comparison of human electroencephalogram (EEG) data with in vitro models
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DOI：
10.1073/pnas.120162397
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发表时间：
2000-06-20
影响因子：
11.1
通讯作者：
Gruzelier, J
中科院分区：
文献类型：
--
作者：
Haenschel, C;Baldeweg, T;Gruzelier, J
使用保持在体外的海马切片的研究已经证明，γ频率范围（30-80 Hz）中的振荡场电位的爆发之后是β 1范围（12-20 Hz）中的较慢振荡。在这项研究中，我们证明了一个可比的γ-β过渡被认为是在人类脑电图（EEC）在响应新的听觉刺激。γ和β 1活性之间的相关性揭示了在人类EEC中这些频带中同步振荡的高度相互依赖性，诱发（刺激锁定）γ振荡先于β 1振荡以响应新的刺激，这表明这可能类似于体外观察到的γ-β转变。β 1振荡是最早的区别性反应，表现出对新刺激的增强，先于宽带事件相关电位（失配负性）的变化。在体外实验中，顶叶皮层诱导β活性的后期峰值总是伴随着潜在的γ频率振荡。体外和人类记录之间的进一步类比是，在最初的新刺激呈现之后，γ振荡和β振荡都明显习惯化。
Investigations using hippocampal slices maintained in vitro have demonstrated that bursts of oscillatory field potentials in the gamma frequency range (30-80 Hz) are followed by a slower oscillation in the beta 1 range (12-20 Hz). In this study, we demonstrate that a comparable gamma-to-beta transition is seen in the human electroencephalogram (EEC) in response to novel auditory stimuli. Correlations between gamma and beta 1 activity revealed a high degree of interdependence of synchronized oscillations in these bands in the human EEC, Evoked (stimulus-locked) gamma oscillations preceded beta 1 oscillations in response to novel stimuli, suggesting that this may be analogous to the gamma-to-beta shift observed in vitro. Beta 1 oscillations were the earliest discriminatory responses to show enhancement to novel stimuli, preceding changes in the broad-band event-related potential (mismatch negativity). Later peaks of induced beta activity over the parietal cortex were always accompanied by an underlying gamma frequency oscillation as seen in vitro. A further analogy between in vitro and human recordings was that both gamma and beta oscillations habituated markedly after the initial novel stimulus presentation.