Quantitative multispectral ex vivo optical evaluation of human ovarian tissue using spatial frequency domain imaging
Quantitative multispectral ex vivo optical evaluation of human ovarian tissue using spatial frequency domain imaging
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DOI：
10.1364/boe.9.002451
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发表时间：
2018-05-01
影响因子：
3.4
通讯作者：
Zhu, Quing
中科院分区：
文献类型：
--
作者：
Nandy, Sreyankar;Hagemann, Ian S.;Zhu, Quing
大约 85-90% 的卵巢癌是癌；这些在临床上表现为累及卵巢的肿块上皮增殖。在本研究中，可见光空间频域成像（SFDI）系统用于对新鲜切除的良性和恶性人类卵巢组织进行多光谱离体成像和定量评估。总共对 11 名接受卵巢切除术的患者的 14 个卵巢进行了研究。使用从 SFDI 图像中提取的七个显着光谱和空间特征的逻辑回归模型，预测组织学证实的浸润性癌的敏感性为 94.06%，特异性为 93.53%。 (C) 2018 年美国光学协会根据 OSA 开放获取出版协议条款
About 85-90% of all ovarian cancers are carcinomas; these manifest clinically as mass-forming epithelial proliferations involving the ovary. In this study, a visible light spatial frequency domain imaging (SFDI) system was used for multispectral ex vivo imaging and quantitative evaluation of freshly excised benign and malignant human ovarian tissues. A total of 14 ovaries from 11 patients undergoing oophorectomy were investigated. Using a logistic regression model with seven significant spectral and spatial features extracted from SFDI images, a sensitivity of 94.06% and specificity of 93.53% were achieved for prediction of histologically confirmed invasive carcinoma. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement