Nucleotide signalling during inflammation.
Nucleotide signalling during inflammation.
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炎症过程中的核苷酸信号传导。
作者：
炎症状态与细胞外核苷酸的释放有关，尤其是三磷酸腺苷。在胞外隔室，ATP主要通过激活嘌呤能P2受体作为信号分子发挥作用。亲代谢性的P2Y受体是G蛋白偶联的，而亲离子性的P2X受体是ATP门控离子通道。在这里，我们讨论通过P2受体的信号事件如何改变炎症或感染性疾病的结果。最近的研究表明，P2X/P2Y信号在启动适当的炎症反应中发挥了作用，这对宿主防御入侵病原体或肿瘤至关重要。相反，在缺血和再灌注损伤、炎症性肠病或急、慢性肺部疾病中，P2X/P2Y信号可以促进慢性炎症。尽管核苷酸信号以前曾用于临床，但研究表明，有越来越多的机会专门针对单个P2受体治疗炎症性或感染性疾病。
Inflammatory conditions are associated with the extracellular release of nucleotides, particularly ATP. In the extracellular compartment, ATP predominantly functions as a signalling molecule through the activation of purinergic P2 receptors. Metabotropic P2Y receptors are G-protein-coupled, whereas ionotropic P2X receptors are ATP-gated ion channels. Here we discuss how signalling events through P2 receptors alter the outcomes of inflammatory or infectious diseases. Recent studies implicate a role for P2X/P2Ysignalling in mounting appropriate inflammatory responses critical for host defence against invading pathogens or tumours. Conversely, P2X/P2Y signalling can promote chronic inflammation during ischaemia and reperfusion injury, inflammatory bowel disease or acute and chronic diseases of the lungs. Although nucleotide signalling has been used clinically in patients before, research indicates an expanding field of opportunities for specifically targeting individual P2 receptors for the treatment of inflammatory or infectious diseases.
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影响因子：
82.9
作者：
通讯作者：
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影响因子：
5.4
作者：
Ben Yebdri, Fethia;Kukulski, Filip;Sevigny, Jean
通讯作者：
Sevigny, Jean
DOI：
10.4049/jimmunol.1001567
发表时间：
2011-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Belikoff BG;Hatfield S;Georgiev P;Ohta A;Lukashev D;Buras JA;Remick DG;Sitkovsky M
通讯作者：
Sitkovsky M
影响因子：
4.4
作者：
Cicko, Sanja;Lucattelli, Monica;Idzko, Marco
通讯作者：
Idzko, Marco
影响因子：
64.8
作者：
通讯作者：
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