ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men
ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men
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DOI：
10.18999/nagjms.78.2.183
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发表时间：
2016-05
影响因子：
0.9
通讯作者：
G. Yin;M. Naito;K. Wakai;Emi Morita;S. Kawai;N. Hamajima;Sadao Suzuki;Y. Kita;T. Takezaki;Keitaro Tanaka;M. Morita;H. Uemura;E. Ozaki;S. Hosono;H. Mikami;M. Kubo;Hideo Tanaka
中科院分区：
文献类型：
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作者：
G. Yin;M. Naito;K. Wakai;Emi Morita;S. Kawai;N. Hamajima;Sadao Suzuki;Y. Kita;T. Takezaki;Keitaro Tanaka;M. Morita;H. Uemura;E. Ozaki;S. Hosono;H. Mikami;M. Kubo;Hideo Tanaka
摘要在流行病学研究中，饮酒和2型糖尿病风险之间的关联是不一致的。这项研究调查了ADH1B和ALDH2基因多态性与日本人空腹血糖水平的关系，以及饮酒与空腹血糖水平之间的关系。这项横断面研究包括907名男性和912名女性，年龄在35-69岁之间。研究对象选自日本六个地区的日本多机构合作队列研究。采用入侵者分析方法对ADH1B和ALDH2基因进行分型。ALDH2 Glu504Lys基因型与男性不同的空腹血糖水平相关(P=0.04)。在携带ALDH2 504Lys等位基因的男性中，平均空腹血糖水平与饮酒呈正相关(P趋势=0.02)，而在携带ALDH2 504Glu/Glu基因型的男性中，平均空腹血糖水平与饮酒无关(P趋势=0.45)，无统计学意义的交互作用(P=0.38)。与不饮酒的男性相比，饮酒与空腹血糖水平升高相关(P趋势=0.002)。ADH1B Arg48His基因多态性与总体空腹血糖水平或分层饮酒后的空腹血糖水平无关。这些发现表明，ALDH2基因多态性与日本男性通过饮酒而产生的不同水平的空腹血糖有关。ALDH2基因多态在饮酒和空腹血糖之间的相互作用值得进一步研究。
ABSTRACT Associations between alcohol consumption and type 2 diabetes risk are inconsistent in epidemiologic studies. This study investigated the associations of ADH1B and ALDH2 polymorphisms with fasting blood glucose levels, and the impact of the associations of alcohol consumption with fasting blood glucose levels in Japanese individuals. This cross-sectional study included 907 men and 912 women, aged 35–69 years. The subjects were selected from among the Japan Multi-institutional Collaborative Cohort study across six areas of Japan. The ADH1B and ALDH2 polymorphisms were genotyped by Invader Assays. The ALDH2 Glu504Lys genotypes were associated with different levels of fasting blood glucose in men (P = 0.04). Mean fasting glucose level was positively associated with alcohol consumption in men with the ALDH2 504 Lys allele (Ptrend = 0.02), but not in men with the ALDH2 504Glu/Glu genotype (Ptrend = 0.45), resulting in no statistically significant interaction (P = 0.38). Alcohol consumption was associated with elevated fasting blood glucose levels compared with non-consumers in men (Ptrend = 0.002). The ADH1B Arg48His polymorphism was not associated with FBG levels overall or after stratification for alcohol consumption. These findings suggest that the ALDH2 polymorphism is associated with different levels of fasting blood glucose through alcohol consumption in Japanese men. The interaction of ALDH2 polymorphisms in the association between alcohol consumption and fasting blood glucose warrants further investigation.