Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies
Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies
复制标题
α-Klotho 能否解开老年人抑郁症和痴呆症之间的钥匙：从动物研究到人类研究。
DOI：
10.1007/s12035-021-02313-0
复制
发表时间：
2021-02-01
影响因子：
5.1
通讯作者：
Li, Rena
中科院分区：
文献类型：
--
作者：
Gao, Xiang;Li, Yuhong;Li, Rena
阿尔法-Klotho以其与衰老相关的功能而闻名，并与神经退行性疾病、加速衰老、过早发病和死亡有关。最近的文献表明，阿尔法-Klotho也参与了精神功能的调节，如认知和精神病。虽然大多数关于α-Klotho的研究都集中在它的抗衰老功能和对痴呆症的保护作用上，但越来越多的证据表明，抑郁症和痴呆症之间有许多共同的症状，而抑郁症被认为是阿尔茨海默病(AD)等痴呆症的临床前阶段。为了了解α-Klotho是否以及如何成为抑郁症和痴呆之间的关键生物学联系，在这篇综述中，我们首先收集了从动物研究到人类临床研究的关于α-Klotho在精神功能中的生物分布和功能的证据，重点放在认知和情绪的调节上。然后，我们讨论并强调了阿尔法-Klotho在精神疾病和认知障碍之间潜在的共同潜在机制。最后，我们假设α-Klotho可能通过调节氧化应激和炎症而在抑郁症和痴呆症之间起到神经生物学联系。
alpha-Klotho is known for its aging-related functions and is associated with neurodegenerative diseases, accelerated aging, premature morbidity, and mortality. Recent literature suggests that alpha-Klotho is also involved in the regulation of mental functions, such as cognition and psychosis. While most of studies of alpha-Klotho are focusing on its anti-aging functions and protective role in dementia, increasing evidence showed many shared symptoms between depression and dementia, while depression has been proposed as the preclinical stage of dementia such as Alzheimer's disease (AD). To see whether and how alpha-Klotho can be a key biological link between depression and dementia, in this review, we first gathered the evidence on biological distribution and function of alpha-Klotho in psychiatric functions from animal studies to human clinical investigations with a focus on the regulation of cognition and mood. Then, we discussed and highlighted the potential common underlying mechanisms of alpha-Klotho between psychiatric diseases and cognitive impairment. Finally, we hypothesized that alpha-Klotho might serve as a neurobiological link between depression and dementia through the regulation of oxidative stress and inflammation.