Endothelium-derived bone morphogenic protein antagonists may counteract the proatherogenic vascular effects of bone morphogenic protein 4.
Endothelium-derived bone morphogenic protein antagonists may counteract the proatherogenic vascular effects of bone morphogenic protein 4.
复制标题
内皮源性骨形态发生蛋白拮抗剂可能抵消骨形态发生蛋白 4 的促动脉粥样硬化血管作用。
DOI：
10.1161/circulationaha.107.726307
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发表时间：
2007
期刊：
影响因子：
37.8
通讯作者：
Ungvari,ZoltanI
中科院分区：
文献类型：
--
作者：
Ungvari,ZoltanI
In the present issue of Circulation, Chang et al1 report novel shear stress–sensitive paracrine mechanisms that regulate the activity of bone morphogenetic proteins (BMPs) in the vascular wall. BMP2 and BMP4 are structurally related members of the transforming growth factor-ß superfamily. Recent studies demonstrated that vascular endothelial and smooth muscle cells are a significant source of BMPs, 2–8 which regulate a host of cellular functions, including cardiovascular development, 9 neovascularization in tumors, 10 and smooth muscle cell chemotaxis in response to vascular injury, 11 and control the balance between proliferation and activation of apoptosis in pulmonary arterial endothelial and smooth muscle cells. 12
